{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:45:19Z","timestamp":1768621519664,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T00:00:00Z","timestamp":1213747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myotonic dystrophy type 1 (DM1) is an autosomal\u2010dominant multisystemic disorder that may rarely be associated with benign and malignant neoplasms. Cases of both thymoma and myasthenia gravis in association with DM1 are extremely rare. A literature review revealed only three prior reports. We present a 51\u2010year\u2010old man with a family history of DM1 and fluctuating diplopia and ptosis, who was found to have acetylcholine receptor\u2013binding antibodies, thymoma, and a clinical presentation compatible with ocular myasthenia gravis as well as positive genetic testing for DM1. Needle electromyographic (EMG) study demonstrated diffuse runs of myotonic discharges in multiple muscles, consistent with the diagnosis of DM1. Single\u2010fiber EMG showed both increased jitter and blocking. Due to somatic instability, which has been shown previously in DM1, the myotonin protein kinase (DMPK) gene appears to act as a tumor suppressor. Therefore, abnormal CTG repeat expansions in the gene could lead to the development of thymoma and myasthenia gravis. Muscle Nerve 38: 916\u2013920, 2008<\/jats:p>","DOI":"10.1002\/mus.21046","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T14:23:12Z","timestamp":1213798992000},"page":"916-920","source":"Crossref","is-referenced-by-count":17,"title":["Myotonic dystrophy type 1 coexisting with myasthenia gravis and thymoma"],"prefix":"10.1002","volume":"38","author":[{"given":"Timothy","family":"Feyma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory T.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)00125-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.05.006"},{"key":"e_1_2_6_4_2","first-page":"498","article-title":"Myasthenia gravis and myotonic dystrophy in the same patient [in Spanish]","volume":"32","author":"Benito\u2010Le\u00f3n J","year":"2001","journal-title":"Rev Neurol"},{"key":"e_1_2_6_5_2","first-page":"405","article-title":"Myotonic dystrophy and thymoma associated with myasthenic behavior on electromyography [in Spanish]","volume":"160","author":"Canovas A","year":"1981","journal-title":"Rev Clin Esp"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.44.9.852-a"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.01.014"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(91)90039-U"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.1998.3036"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.Supplement_1.1417"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.03.023"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080507"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913913"},{"key":"e_1_2_6_14_2","first-page":"1","article-title":"Changes of single fiber electromyography in patients with inflammatory myopathies","volume":"20","author":"Jian F","year":"2005","journal-title":"Chin Med Sci J"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199909)22:9<1271::AID-MUS16>3.0.CO;2-D"},{"key":"e_1_2_6_16_2","first-page":"S104","article-title":"Profiles of neuromuscular disease: myotonic muscular dystrophy","volume":"74","author":"Johnson ER","year":"1995","journal-title":"Am J Phys Med Rehabil"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.5.534"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199705)20:5<622::AID-MUS16>3.0.CO;2-Y"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.41.312"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880100404"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.2061"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.44.2.173"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052426"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1980.tb03827.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<804::AID-MUS19>3.0.CO;2-E"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb51311.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.053"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199909)22:9<1297::AID-MUS22>3.0.CO;2-C"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1041255"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1233"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-424X(09)70143-6"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.6.546"},{"key":"e_1_2_6_33_2","first-page":"175","article-title":"Facioscapulohumeral muscular dystrophy. 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