{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:33:00Z","timestamp":1790839980310,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T00:00:00Z","timestamp":1216339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spinal and bulbar muscular atrophy (SBMA) is an adult\u2010onset motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. Because the progression of SBMA is slow, it is plausible to identify biomarkers that monitor disease course for therapeutic development. To verify whether the 6\u2010min walk test (6MWT) is a biomarker of SBMA, we performed the 6MWT in 35 genetically confirmed patients and in 29 age\u2010matched healthy controls. The walk distance covered within 6 min (6MWD) was significantly less in SBMA than it was in controls (323.3 \u00b1 143.9 m and 637.6 \u00b1 94.2 m, respectively; <jats:italic>P<\/jats:italic> &lt; 0.001). In test\u2013retest analysis, the intraclass correlation coefficient for the 6MWD was high in SBMA patients (<jats:italic>r<\/jats:italic> = 0.982). In a 1\u2010year follow\u2010up the 6MWD significantly decreased at a rate of 11.3% per year. Our observations suggest that the 6MWT is a biomarker that can be used to monitor progression of motor impairment in SBMA. Muscle Nerve, 2008<\/jats:p>","DOI":"10.1002\/mus.21077","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T20:39:19Z","timestamp":1216413559000},"page":"964-971","source":"Crossref","is-referenced-by-count":59,"title":["Walking capacity evaluated by the 6\u2010minute walk test in spinal and bulbar muscular atrophy"],"prefix":"10.1002","volume":"38","author":[{"given":"Yu","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Banno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoshi","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Atsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh381"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1191\/0269215506cr964oa"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.12.2005"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl096"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20735"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968306298937"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.11.021"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000195129.95220.77"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320517"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.10.2055"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs0302.104195"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005344403603"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1691"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70447-1"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.03.014"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.014"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm878"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506249102"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.7.671"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.08.003"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/352077a0"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.10.013"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh131"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2000.9172"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000115283"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638280500164479"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.1.209"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1.256"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.12.1921"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm289"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.9.1253"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1298"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.01.046"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00303-6"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1547"}],"container-title":["Muscle &amp; 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