{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:01:15Z","timestamp":1792602075527,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,10,23]],"date-time":"2008-10-23T00:00:00Z","timestamp":1224720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Orphan Products Development Program of the U.S. FDA","award":["FD-R-002154)"],"award-info":[{"award-number":["FD-R-002154)"]}]},{"name":"F. Hoffmann-La Roche, Ltd. (Roche)","award":["CEL248)"],"award-info":[{"award-number":["CEL248)"]}]},{"name":"Aspreva Pharmaceuticals"},{"name":"General Clinical Research Center (GCRC) of the National Center for Research Resources"},{"name":"NIH","award":["MO1-RR00034"],"award-info":[{"award-number":["MO1-RR00034"]}]},{"name":"NIH","award":["M01-RR00044"],"award-info":[{"award-number":["M01-RR00044"]}]},{"name":"NIH","award":["M01-RR01346"],"award-info":[{"award-number":["M01-RR01346"]}]},{"name":"NIH","award":["M01-RR023940"],"award-info":[{"award-number":["M01-RR023940"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We determined the strength of correlation among, and responsiveness of, outcome measures used in a multicenter, double\u2010blind, placebo\u2010controlled trial of mycophenolate mofetil in combination with prednisone in myasthenia gravis (MG). The primary efficacy measure was the change from baseline in the Quantitative MG (QMG) score at week 12. Secondary outcome measures included the MG\u2014Activities of Daily Living profile (MG\u2010ADL) and MG Manual Muscle Test (MMT). The measures were collected at baseline and at weeks 4, 8, and 12 in the blinded study and at weeks 16, 20, 28, and 36 in an optional open\u2010label extension. At baseline, the QMG was moderately correlated with the MG\u2010ADL (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.55,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001) and the MMT (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.53,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001), but the correlation between the MG\u2010ADL and the MMT was lower (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.30,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.007). These findings were similar at weeks 4, 8, and 12. Similar correlations were found among the changes in scores from baseline at weeks 12 and 36. The MMT and MG\u2010ADL appeared to be the most sensitive measures for changes in MG status at weeks 12 and 36. Although a task force has recommended use of the QMG in prospective MG trials, the MMT and MG\u2010ADL appear to be suitable alternatives and offer potential advantages. No special training or equipment is required, and they take less time. \u00a9 2008 Wiley Periodicals, Inc. Muscle Nerve 38: 1429\u20131433, 2008\n                  <\/jats:p>","DOI":"10.1002\/mus.21142","type":"journal-article","created":{"date-parts":[[2008,10,23]],"date-time":"2008-10-23T10:34:15Z","timestamp":1224758055000},"page":"1429-1433","source":"Crossref","is-referenced-by-count":39,"title":["Comparison of outcome measures from a trial of Mycophenolate mofetil in myasthenia gravis"],"prefix":"10.1002","volume":"38","author":[{"given":"Gil I.","family":"Wolfe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Barohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel P.","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,23]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.056"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11015.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163988.28892.79"},{"key":"e_1_2_8_5_2","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen JJ","year":"1988"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90069-5"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.8.1130"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/17482960600888156"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.12.001"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000094122.88929.0B"},{"key":"e_1_2_8_12_2","article-title":"A trial of mycophenolate mofetil with prednisone as initial immunotherapy in myasthenia gravis","author":"Muscle Study Group","journal-title":"Neurology"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085833"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2004.07.013"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000147242.92691.71"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.057"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050585"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144345.49510.4E"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05186-2"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1487"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21142","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.21142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T21:16:26Z","timestamp":1695849386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.21142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,23]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1002\/mus.21142"],"URL":"https:\/\/doi.org\/10.1002\/mus.21142","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,23]]}}}