{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:27:56Z","timestamp":1764102476238},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a patient with uncontrolled Crohn's disease who presented with progressive weakness of proximal muscles and a marked elevation of serum creatine kinase. Muscle biopsy from the left deltoid exhibited myositic changes with inflammatory infiltrates in the perimysium, endomysium, and perivascular locations. Most were stained as CD68\u2010positive macrophages, whereas some were CD4\u2010 and CD8\u2010positive T lymphocytes. Due to uncontrolled bowel inflammation, several fistulae were found in the descending colon, and partial colectomy was performed. An examination of the resected colon exhibited inflammation of the bowel structure surrounded mainly by CD68\u2010positive macrophages. The histopathological findings of the descending colon were analogous to those of the muscle. After an increased dose of mesalazine and partial colectomy, her muscle symptoms improved. These findings suggest that the myositis in Crohn's disease is immune\u2010mediated and that treatment of bowel inflammation should be emphasized as opposed to steroid or other immunosuppressive therapy. \u00a9 2008 Wiley Periodicals, Inc. Muscle Nerve 39: 101\u2013105, 2009<\/jats:p>","DOI":"10.1002\/mus.21164","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T19:51:53Z","timestamp":1229025113000},"page":"101-105","source":"Crossref","is-referenced-by-count":18,"title":["Immune\u2010mediated myositis in Crohn's disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Takashi","family":"Shimoyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoharu","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"583","article-title":"Myositis associated with Crohn's colitis","volume":"81","author":"Al\u2010Kawas FH","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200203000-00006"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050097"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-002-0679-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023009"},{"key":"e_1_2_6_7_2","first-page":"1259","article-title":"Muscle involvement in Crohn disease","volume":"135","author":"Dioszeghy P","year":"1994","journal-title":"Orv Hetil"},{"key":"e_1_2_6_8_2","first-page":"880","article-title":"Crohn's disease and gastrocnemius vasculitis: two new cases","volume":"92","author":"Disdier P","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90508-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000199251"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.30.441"},{"key":"e_1_2_6_12_2","first-page":"150","article-title":"Atypical inflammatory myopathy associated with Crohn's disease","volume":"15","author":"Heuss D","year":"1996","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_13_2","first-page":"2269","article-title":"Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL\u201023\/IFN\u2010gamma axis","volume":"118","author":"Kamada N","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018825301263"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197610072951506"},{"key":"e_1_2_6_16_2","first-page":"711","article-title":"Extracolonic diagnoses in ulcerative colitis: an epidemiological study","volume":"85","author":"Monsen U","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0195"},{"key":"e_1_2_6_18_2","first-page":"1776","volume-title":"Harrison's principles of internal medicine","author":"Sonia F","year":"2008"},{"key":"e_1_2_6_19_2","first-page":"631","volume-title":"Clinical gastroenterology","author":"Spiro HM","year":"1970"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90323-7"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21164","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.21164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T16:48:31Z","timestamp":1697129311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.21164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,11]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/mus.21164"],"URL":"https:\/\/doi.org\/10.1002\/mus.21164","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,11]]}}}