{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:51:30Z","timestamp":1790905890062,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T00:00:00Z","timestamp":1231891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The lack of dystrophin in\n                    <jats:italic>mdx<\/jats:italic>\n                    mice and in Duchenne muscular dystrophy causes sarcolemmal breakdown and increased calcium influx followed by myonecrosis. We examined whether the calcium channel blockers diltiazem and verapamil protect dystrophic muscles from degeneration.\n                    <jats:italic>Mdx<\/jats:italic>\n                    mice received daily intraperitoneal injections of diltiazem or verapamil for 18 days, followed by removal of the sternomastoid, diaphragm, tibialis anterior, and cardiac muscles. Control\n                    <jats:italic>mdx<\/jats:italic>\n                    mice were injected with saline. Both drugs significantly decreased blood creatine kinase levels. Total calcium content was significantly higher in\n                    <jats:italic>mdx<\/jats:italic>\n                    muscles than in control C57Bl\/10. Verapamil and diltiazem reduced total calcium content only in diaphragm and cardiac muscle. Histological analysis showed that diltiazem significantly attenuated myonecrosis in diaphragm. Immunoblots showed a significant increase of calsequestrin and \u03b2\u2010dystroglycan levels in some diltiazem\u2010 and verapamil\u2010treated muscles. Possible interactions of these drugs with the sarcoplasmic reticulum and sarcolemma may also contribute to the improvement of the dystrophic phenotype. Muscle Nerve 39: 167\u2013176, 2009\n                  <\/jats:p>","DOI":"10.1002\/mus.21188","type":"journal-article","created":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T16:28:11Z","timestamp":1231950491000},"page":"167-176","source":"Crossref","is-referenced-by-count":36,"title":["Diltiazem and verapamil protect dystrophin\u2010deficient muscle fibers of\n                    <i>MDX<\/i>\n                    mice from degeneration: A potential role in calcium buffering and sarcolemmal stability"],"prefix":"10.1002","volume":"39","author":[{"given":"Cintia Yuri","family":"Matsumura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Pertille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza C.P.","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Santo 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