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Gender ratios and the proportion of seropositive patients differ in the pre\u2010 and postpubertal age groups. The diagnostic evaluation is similar to that in adults, although special techniques are sometimes necessary to perform single\u2010fiber electromyography in younger patients. Therapeutic decisions in affected children and adolescents are complicated by the greater long\u2010term consequences of using steroids, and thus other interventions, such as intravenous immunoglobulin (IVIg) and plasmapheresis, may play a greater therapeutic role in this population than in adults. Steroid\u2010sparing agents may contribute to the management of refractory cases, but they should be used with caution due to the risk of malignancy. 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