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PDMP levels in active PM\/DM patients (median 13.3 U\/ml, interquartile range 9.9\u201320.7 U\/ml, <jats:italic>n<\/jats:italic> = 16) and those in patients undergoing treatment (12.1 U\/ml, 7.4\u201316.7 U\/ml, <jats:italic>n<\/jats:italic> = 12) were significantly higher than in controls (6.5 U\/ml, 5.0\u20138.4 U\/ml, <jats:italic>n<\/jats:italic> = 26, vs. active, <jats:italic>P<\/jats:italic> = 0.0001; vs. treatment, <jats:italic>P<\/jats:italic> = 0.004). In a paired sampling study, PDMP decreased significantly after glucocorticoid treatment (<jats:italic>P<\/jats:italic> = 0.04). PDMP in the active PM\/DM patients correlated significantly with serum C\u2010reactive protein levels (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = 0.67, <jats:italic>P<\/jats:italic> = 0.01). These results suggest that platelets may play an important role in the inflammatory process, and that PDMP level could be a useful marker of inflammatory activity in PM\/DM patients. Muscle Nerve 39: 586\u2013590, 2009<\/jats:p>","DOI":"10.1002\/mus.21311","type":"journal-article","created":{"date-parts":[[2009,4,3]],"date-time":"2009-04-03T14:17:35Z","timestamp":1238768255000},"page":"586-590","source":"Crossref","is-referenced-by-count":18,"title":["Measurement of platelet\u2010derived microparticle levels using an enzyme\u2010linked immunosorbent assay in polymyositis and dermatomyositis 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