{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:32Z","timestamp":1786978232218,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T00:00:00Z","timestamp":1236038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myasthenia gravis (MG) is an autoimmune disorder usually caused by antibodies against either the acetylcholine receptor (AChR) or muscle\u2010specific tyrosine kinase (MuSK) at the neuromuscular junction. Neuromuscular transmission failure results in muscle fatigue and weakness that can be treated symptomatically with acetylcholinesterase inhibitors (AChEIs). Long\u2010term treatment with nonselective AChEIs may have considerable drawbacks; thus, this medication is ideally tapered when strength improves. Patients with AChR antibodies respond beneficially to treatment, whereas patients with MuSK antibodies generally do not. Recently, the selective AChEI EN101, which specifically targets the isoform of \u201cread\u2010through\u201d AChE (AChE\u2010R), has been developed and may be of importance for symptomatic relief in AChR\u2010antibody seropositive MG. This article is a review of the mechanisms, therapeutic effects, and drawbacks, with both old and new AChEIs in MG. Muscle Nerve, 2009<\/jats:p>","DOI":"10.1002\/mus.21319","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T14:52:06Z","timestamp":1236091926000},"page":"724-728","source":"Crossref","is-referenced-by-count":27,"title":["Acetylcholinesterase inhibitors in MG: To be or not to be?"],"prefix":"10.1002","volume":"39","author":[{"given":"Anna Rostedt","family":"Punga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"St\u00e5lberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,3]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110107"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000267884.39468.7a"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.6.2471"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2006.01.003"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0609com"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb33731.x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.12.1273"},{"key":"e_1_2_10_9_2","first-page":"267","article-title":"Immune complexes (IgG and C3) at the motor end\u2010plate in myasthenia gravis: ultrastructural and light microscopic localization and electrophysiologic correlations","volume":"52","author":"Engel AG","year":"1977","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg223"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(01)00093-3"},{"key":"e_1_2_10_12_2","first-page":"486","article-title":"Immune response in rabbits to a cholinergic receptor protein: possibly a model for myasthenia gravis","volume":"360","author":"Heilbronn E","year":"1974","journal-title":"Medica Int Congr Series Recent Advances Myologi"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050307"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880171208"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200101)31:1<225::AID-IMMU225>3.0.CO;2-0"},{"key":"e_1_2_10_16_2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0022-3565(25)31235-8","article-title":"Neostigmine\u2010induced alterations at the mammalian neuromuscular junction. 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