{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:31:03Z","timestamp":1780975863102,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:00:00Z","timestamp":1247702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH (National Institute of Neurologic Disorders and Stroke","award":["K08NS058800-01"],"award-info":[{"award-number":["K08NS058800-01"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["RO1 AI 058190-01"],"award-info":[{"award-number":["RO1 AI 058190-01"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100003157","name":"Myasthenia Gravis Foundation of America","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100003157","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown increased expression of acetylcholine receptor\u2010alpha (AChR\u2010\u03b1) subunit transcripts in myasthenia gravis (MG) and experimental MG (EAMG), but none examined the functional properties of this overexpression. In this study we examined the mRNA and protein expression of AChR\u2010\u03b1 as well as the pattern of \u03b1\u2010bungarotoxin labeling in muscle tissue from EAMG mice with varying disease severity. AChR\u2010\u03b1 expression was increased considerably in endplates from mice with severe EAMG, but it was distinct and greatly in excess of \u03b1\u2010bungarotoxin labeling. This \u201caberrant expression\u201d occurred in mice with morphologic endplate damage, and the pattern of complement and immunoglobulin deposition in muscle from these mice appeared to mirror the pattern of AChR\u2010\u03b1 expression. The loss of <jats:italic>functional<\/jats:italic> AChR in severe MG increases transcription of AChR\u2010\u03b1 mRNA, but the expressed protein is \u201cfunctionally inert,\u201d failing to compensate for loss of AChR. This enhanced expression of AChR may play a role in driving the ongoing autoimmune response. Muscle Nerve 40: 279\u2013286, 2009<\/jats:p>","DOI":"10.1002\/mus.21371","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T06:46:45Z","timestamp":1247899605000},"page":"279-286","source":"Crossref","is-referenced-by-count":12,"title":["Acetylcholine receptor\u2010\u03b1 subunit expression in myasthenia gravis: A role for the autoantigen in pathogenesis?"],"prefix":"10.1002","volume":"40","author":[{"given":"Jian Rong","family":"Sheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bellur S.","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Meriggioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri916"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29894"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80442-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)80932-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117302"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1248"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4807"},{"key":"e_1_2_6_9_2","series-title":"Current protocols of immunology","first-page":"8.1","author":"Wu B","year":"1997"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.03.509"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5296"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb30741.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07378.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp021090"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00200-9"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.11.1054"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00126-X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.10.1077"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri724"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14255"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)81399-S"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.08.013"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.2.233"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930801929021"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-5250-4_30"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0760"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21371","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.21371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:04:29Z","timestamp":1696971869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.21371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,16]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1002\/mus.21371"],"URL":"https:\/\/doi.org\/10.1002\/mus.21371","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,16]]}}}