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The control group was administered a placebo, the standard\u2010dose group was given 3 mg\/kg of edaravone intraperitoneally every 24 hours, and the low\u2010dose group was given 1 mg\/kg of edaravone. At 7 days after reperfusion, neurological and electrophysiological parameters were improved in the standard\u2010dose group as compared with the control group. After 14 days, however, these differences were no longer observed. After 21 days, persistent edema and nerve fiber degeneration were noted in the standard\u2010dose group, but not in the control or low\u2010dose groups. Edaravone was effective during the early reperfusion period, but chronic inhibition of reactive oxygen species may be detrimental for nerve regeneration after ischemia\u2013reperfusion injury. Further studies are necessary to confirm the long\u2010term influence of edaravone. 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