{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:52:50Z","timestamp":1784173970995,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T00:00:00Z","timestamp":1248134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Creatinine as a marker of renal function has limited value in Duchenne muscular dystrophy (DMD) because of reduced muscle mass. Alternative methods of assessing renal function are sorely needed. Cystatin C, a nonglycosylated protein unaffected by muscle mass, is potentially an ideal biomarker of nephrotoxicity for this population but requires validation. In all, 75 subjects were recruited: 35 DMD (mean age 10.8 \u00b1 5.4 years, corticosteroids <jats:italic>n<\/jats:italic> = 19, ambulatory <jats:italic>n<\/jats:italic> = 26), 29 healthy controls, 10 with renal disease, and one DMD with renal failure. Cystatin C levels in DMD were normal irrespective of age, ambulation, or corticosteroid treatment. Serum cystatin C was 0.67 \u00b1 0.11 mg\/l compared to normal controls 0.69 \u00b1 0.09. mg\/l. In these same individuals serum creatinine was severely reduced (0.27 \u00b1 0.12 mg\/dl) versus normals (0.75 \u00b1 0.15 mg\/dl, <jats:italic>P<\/jats:italic> &lt; 0.01). In one DMD subject in renal failure, cystatin C was elevated. This study demonstrates the potential value of cystatin C as a biomarker for monitoring renal function in DMD. Its applicability extends to other neuromuscular diseases. Muscle Nerve, 2009<\/jats:p>","DOI":"10.1002\/mus.21420","type":"journal-article","created":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T18:45:10Z","timestamp":1248201910000},"page":"438-442","source":"Crossref","is-referenced-by-count":94,"title":["Utility of cystatin C to monitor renal function in duchenne muscular dystrophy"],"prefix":"10.1002","volume":"40","author":[{"given":"Laurence","family":"Viollet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Gailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil R.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin 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