{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:55:57Z","timestamp":1780606557908,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,10,8]],"date-time":"2009-10-08T00:00:00Z","timestamp":1254960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective was to assess which clinical factors of patients with myasthenia gravis (MG) are associated with responsiveness to calcineurin inhibitors (CNIs, cyclosporine and tacrolimus). We retrospectively analyzed the 6\u2010month effects of CNIs in 62 MG patients. We excluded the influence of other immune treatments and determined factors associated with response to CNIs. The frequency of patients who achieved neither a \u22653\u2010point reduction in quantitative MG score nor a \u226525% reduction in daily dose of prednisolone (poor responders) reached 35.5% (22\/62) and 64.5% (40\/62), respectively, compared with patients who achieved at least one of these improvements (responders). Neither dose nor blood concentration of CNIs differed between groups. Multivariate logistic regression analysis revealed time since onset of disease [odds ratio (OR) = 0.85, <jats:italic>P<\/jats:italic> = 0.005] and presence of thymoma (OR = 5.56, <jats:italic>P<\/jats:italic> = 0.05) as clinical factors that predict response to CNIs. As for MG\u2010related autoantibody status, an autoantibody against a voltage\u2010gated potassium channel, Kv1.4, was associated with response (OR = 9.01, <jats:italic>P<\/jats:italic> = 0.04) and showed a correlation with the presence of thymoma (<jats:italic>P<\/jats:italic> &lt; 0.01). In MG, the early stages of disease and thymoma\u2010associated MG are responsive to treatment with CNIs. Muscle Nerve, 2010<\/jats:p>","DOI":"10.1002\/mus.21462","type":"journal-article","created":{"date-parts":[[2009,10,8]],"date-time":"2009-10-08T14:29:13Z","timestamp":1255012153000},"page":"212-218","source":"Crossref","is-referenced-by-count":46,"title":["Factors associated with response to calcineurin inhibitors in myasthenia gravis"],"prefix":"10.1002","volume":"41","author":[{"given":"Yuriko","family":"Nagane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiaki","family":"Utsugisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.180.4088.871"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.4049\/jimmunol.141.10.3361","article-title":"Regulation of antibody production by helper T cell clones in experimental autoimmune myasthenia gravis","volume":"141","author":"Fujii Y","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114948"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150316"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312373.67493.7f"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2003.09.016"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.042176"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085833"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02130.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.40.1256"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90111-J"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161130-00006"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703193161205"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb22937.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050141"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.3.448"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10018"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00378.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh077"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl084"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.8.1121"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.11.1596"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.6.885"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11015.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312374.95186.cc"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.031"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198003000-00005"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000174560.35190.84"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.06.027"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70060-7"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000125254.99397.68"},{"key":"e_1_2_5_34_2","doi-asserted-by":"crossref","first-page":"22992","DOI":"10.1016\/S0021-9258(19)49416-7","article-title":"The calcium release channel of sarcoplasmic reticulum is modulated by FK\u2010506\u2010binding protein. 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