{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:41:16Z","timestamp":1789990876235,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T00:00:00Z","timestamp":1256860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We performed a retrospective chart review on 53 muscle\u2010specific kinase antibody (MuSK\u2010Ab)\u2010positive myasthenia gravis (MG) patients at nine university\u2010based centers in the U.S. Of these, 66% were Caucasian, 85% were women, and age of onset was 9\u201379 years. Twenty\u2010seven patients were nonresponsive to anticholinesterase therapy. Myasthenia Gravis Foundation of America improvement status was achieved in 53% patients on corticosteroids, 51% with plasma exchange, and in 20% on intravenous immunoglobulin (IVIG). Thymectomy was beneficial in 7\/18 patients at 3 years. Long\u2010term (\u22653 years) outcome was very favorable in 58% of patients who achieved remission and\/or minimal manifestation status. Overall, 73% improved. There was one MG\u2010related death. This survey reinforces several cardinal features of MuSK\u2010Ab\u2010positive MG, including prominent bulbar involvement and anticholinesterase nonresponsiveness. Facial or tongue atrophy was rare. Most patients respond favorably to immunotherapy. The best clinical response was to corticosteroids and plasma exchange, and the poorest response was to IVIG. Long\u2010term outcome is favorable in about 60% of cases. 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