{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:33:51Z","timestamp":1790688831051,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,12]],"date-time":"2010-03-12T00:00:00Z","timestamp":1268352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose was to estimate the frequency, characteristics, and risk factors of HIV\u2010associated distal sensory polyneuropathy (DSP) among South Africans who attend an urban community\u2010based clinic. In a cross\u2010sectional study, neuropathy status was determined in 598 HIV\u2010infected adults using validated tools (Brief Peripheral Neuropathy Screen and a modified version of the Total Neuropathy Score) to categorize subjects as DSP versus no DSP. Symptomatic DSP (SDSP) required the presence of at least two neuropathic signs together with symptoms. Clinical, anthropometric, and laboratory evaluations were prospectively performed. CD4 counts, antiretroviral therapy (ART), and questionnaires regarding previous tuberculosis (TB) and alcohol exposure were collected retrospectively. Approximately half (49%) of the study population were diagnosed with DSP, and 30% of the study population were diagnosed with SDSP. In multivariate analyses the odds ratio (OR) (95% confidence interval) of DSP were independently associated with ART use (OR 1.7, 1.0\u20132.9), age (per 10 year increment) (OR 1.7, 1.4\u20132.2), and prior TB (OR 2.0, 1.3\u20133.0). Pain or paresthesias were reported as moderately severe by 70% of those with SDSP. Stavudine use was significantly associated with DSP. DSP is a clinically significant problem in urban HIV\u2010infected Africans. Our findings raise the possibility that the incidence of DSP may be reduced with avoidance of stavudine\u2010containing regimens in older subjects, especially with a history of prior TB infection. Muscle Nerve, 2010<\/jats:p>","DOI":"10.1002\/mus.21535","type":"journal-article","created":{"date-parts":[[2010,3,12]],"date-time":"2010-03-12T17:47:59Z","timestamp":1268416079000},"page":"599-606","source":"Crossref","is-referenced-by-count":91,"title":["HIV neuropathy in South Africans: Frequency, characteristics, and risk factors"],"prefix":"10.1002","volume":"41","author":[{"given":"Jean","family":"Maritz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Benatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel A.","family":"Dave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor B.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motasim","family":"Badri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi S.","family":"Levitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannine M.","family":"Heckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,12]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"UNAIDS. 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South African National Guidelines on Nutrition for People Living with TB HIV\/AIDS and other Chronic Debilitating Conditions. 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