{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:04:57Z","timestamp":1791669897374,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Walking abnormalities are prominent in Duchenne muscular dystrophy (DMD). We modified the 6\u2010minute walk test (6MWT) for use as an outcome measure in patients with DMD and evaluated its performance in 21 ambulatory boys with DMD and 34 healthy boys, ages 4 to 12 years. Boys with DMD were tested twice, \u223c1 week apart; controls were tested once. The groups had similar age, height, and weight. All tests were completed. Boys who fell recovered rapidly from falls without injury. Mean \u00b1 SD [range] 6\u2010minute walk distance (6MWD) was lower in boys with DMD than in controls (366 \u00b1 83 [125\u2013481] m vs. 621 \u00b1 68 [479\u2013754] m; <jats:italic>P<\/jats:italic> &lt; 0.0001; unpaired <jats:italic>t<\/jats:italic>\u2010test). Test\u2010retest correlation for boys with DMD was high (<jats:italic>r<\/jats:italic> = 0.91). Stride length (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.89; <jats:italic>P<\/jats:italic> &lt; 0.0001) was the major determinant of 6MWD for both boys with DMD and controls. A modified 6MWT is feasible and safe, documents disease\u2010related limitations on ambulation, is reproducible, and offers a new outcome measure for DMD natural history and therapeutic trials. Muscle Nerve, 2010<\/jats:p>","DOI":"10.1002\/mus.21544","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T22:22:54Z","timestamp":1259187774000},"page":"500-510","source":"Crossref","is-referenced-by-count":354,"title":["The 6\u2010minute walk test as a new outcome measure in Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"41","author":[{"given":"Craig M.","family":"McDonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik K.","family":"Henricson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay J.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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