{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:49:22Z","timestamp":1790704162619,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,5,7]],"date-time":"2010-05-07T00:00:00Z","timestamp":1273190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytochrome <jats:italic>b<\/jats:italic> mutations are rare causes of exercise intolerance. We report an 18\u2010year\u2010old man with exercise intolerance since childhood, resting lactic acidosis, cytochrome <jats:italic>c<\/jats:italic> oxidase (COX)\u2010positive ragged\u2010red fibers, and isolated muscle complex III deficiency due to a heteroplasmic m.14849T&gt;C mutation in <jats:italic>cytochrome<\/jats:italic>\n<jats:italic>b<\/jats:italic>. We review previously described patients carrying mutations in the same gene. COX\u2010positive ragged\u2010red fibers together with exercise intolerance and lactic acidemia provide a clue for the diagnosis of this rare mitochondrial disorder. Muscle Nerve, 2010<\/jats:p>","DOI":"10.1002\/mus.21649","type":"journal-article","created":{"date-parts":[[2010,5,7]],"date-time":"2010-05-07T22:37:36Z","timestamp":1273271856000},"page":"136-140","source":"Crossref","is-referenced-by-count":22,"title":["Exercise intolerance due to cytochrome <i>b<\/i> mutation"],"prefix":"10.1002","volume":"42","author":[{"given":"Rami","family":"Massie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee\u2010Jun C.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Milone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12364.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80984-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"12308","DOI":"10.1016\/S0021-9258(17)44175-5","article-title":"Topographical orientation of complex III in the yeast mitochondrial membrane","volume":"258","author":"Sidhu A","year":"1983","journal-title":"J Biol Chem"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.1996.0053"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng706"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-0946-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.03.020"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909303411404"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20807"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199901)45:1<130::AID-ART21>3.0.CO;2-Z"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/316900"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10151"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1224"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(93)90123-2"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb00451.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1444"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199901)45:1<127::AID-ART20>3.0.CO;2-Y"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200678"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(01)00244-9"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10429"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00462-8"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04779.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050988"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200009000-00008"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/3108"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5460.2017"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880181423"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199906)45:6<820::AID-ANA22>3.0.CO;2-W"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000033795.17156.00"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1996)8:3<216::AID-HUMU4>3.0.CO;2-7"}],"container-title":["Muscle &amp; 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