{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:25Z","timestamp":1791300505315,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T00:00:00Z","timestamp":1271203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The causes of perifascicular myofiber atrophy and capillary pathology in dermatomyositis are incompletely understood. We studied 11 dermatomyositis muscles by histochemistry, immunohistochemistry, and ultrastructure. We found that endomysial capillaries within regions of perifascicular atrophy are not entirely lost, but they have reduced size, endothelial loss, C5b9 complement deposits, and relatively preserved connective tissue molecules and pericytes. In all muscles, the perimysium varies regionally. Some areas contain intermediate\u2010sized vessels. Others are avascular. In dermatomyositis, vascular perimysium contains abnormal vessel fragments, perivascular inflammation, and increased PECAM\u20101. Perifascicular myofiber atrophy and capillary pathology are concentrated near the avascular perimysium. We conclude that both perimysial intermediate\u2010sized vessels and endomysial capillaries within regions of perifascicular myofiber atrophy are abnormal in dermatomyositis. Capillary damage and myofiber atrophy are concentrated in regions distant from intermediate\u2010sized perimysial vessels. Chronic immune vascular damage and insufficiency in dermatomyositis may cause ischemia, myofiber atrophy, and capillary damage in \u201cwatershed\u201d regions of muscle near the avascular perimysium. Muscle Nerve, 2010<\/jats:p>","DOI":"10.1002\/mus.21651","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T23:39:13Z","timestamp":1271288353000},"page":"53-61","source":"Crossref","is-referenced-by-count":53,"title":["Vascular pathology in dermatomyositis and anatomic relations to myopathology"],"prefix":"10.1002","volume":"42","author":[{"given":"Alan","family":"Pestronk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rati","family":"Choksi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000131751"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60955-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270402"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602063140601"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22993"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23012"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000291619.17160.b8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-004-2194-6"},{"key":"e_1_2_6_10_2","unstructured":"PestronkA.Muscle biopsy. Neuromuscular Disease Center:http:\/\/neuromuscular.wustl.edu\/pathol\/dermmyo.htm#pfmito(accessed November 2009)."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.4.472"},{"key":"e_1_2_6_12_2","unstructured":"PestronkA.Muscle biopsy. Neuromuscular Disease Center:http:\/\/neuromuscular.wustl.edu\/pathol\/jo1.htm(accessed November 2009)."},{"key":"e_1_2_6_13_2","unstructured":"PestronkA.Muscle biopsy. Neuromuscular Disease Center:http:\/\/neuromuscular.wustl.edu\/lab\/mbiopsy.htm#stain(accessed November 2009)."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21822"},{"key":"e_1_2_6_15_2","first-page":"557","volume-title":"Pathology of skeletal muscle","author":"Carpenter S","year":"2001"},{"key":"e_1_2_6_16_2","first-page":"530","volume-title":"Muscle biopsy. A practical approach","author":"Dubowitz V","year":"2007"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292704"},{"key":"e_1_2_6_18_2","first-page":"103","article-title":"Case of dermato\u2010myositis in a child, with pathologic report","volume":"5","author":"Batten FE","year":"1912","journal-title":"Proc R Soc Med"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780030502"},{"key":"e_1_2_6_20_2","first-page":"333","article-title":"What more can we learn from muscle histopathology in children with dermatomyositis\/polymyositis?","volume":"24","author":"Wargula JC","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24411"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.6.1312"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23884"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.639161"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2007.11.003"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8088"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90374.2008"},{"key":"e_1_2_6_28_2","article-title":"Interferon\u2010stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy","author":"Salajegheh M","journal-title":"Ann Neurol"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21651","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.21651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:06:32Z","timestamp":1695474392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.21651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,24]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1002\/mus.21651"],"URL":"https:\/\/doi.org\/10.1002\/mus.21651","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,24]]}}}