{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:24:30Z","timestamp":1788870270554,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T00:00:00Z","timestamp":1279843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["NS16333"],"award-info":[{"award-number":["NS16333"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Roman Reed","award":["RR02-056"],"award-info":[{"award-number":["RR02-056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The extent and mechanisms by which neural input regulates skeletal muscle mass remain largely unknown. Adult spinal cord isolated (SI) rats were implanted unilaterally with a microstimulator, whereas the contralateral limb served as SI control (SI\u2010C). A 100\u2010H\n                    <jats:sc>Z<\/jats:sc>\n                    , 1\u2010s stimulus was delivered every 30 s for 5 min, followed by a 5\u2010min rest. This was repeated six times consecutively (SI\u2010Stim1) or with a 9\u2010h interval after the third bout (SI\u2010Stim2) for 30 days (1 min of daily activity). SI\u2010Stim1 and SI\u2010Stim2 paradigms attenuated plantaris atrophy by 20% and 38%, respectively, whereas only SI\u2010Stim2 blunted soleus atrophy (24%) relative to SI\u2010C. Muscle mass changes occurred independent of the IGF\u20101\/PI3K\/Akt pathway. No relationships between SI or electromechanical stimulation and expression of several atrophy markers were observed. These data suggest that regulatory mechanisms for maintaining muscle mass previously shown in acute states of atrophy differ substantially from those observed in chronic states. Muscle Nerve, 2010\n                  <\/jats:p>","DOI":"10.1002\/mus.21720","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T14:01:28Z","timestamp":1279893688000},"page":"410-421","source":"Crossref","is-referenced-by-count":6,"title":["Electromechanical modulation of catabolic and anabolic pathways in chronically inactive, but neurally intact, muscles"],"prefix":"10.1002","volume":"42","author":[{"given":"Jung A.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland R.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Reggie","family":"Edgerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10189"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000233797.24035.35"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010083"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00545.2004"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00173.2002"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101-1014"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.116715"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101-1009"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00073.2004"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407517200"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00400-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199803)21:3<375::AID-MUS12>3.0.CO;2-Z"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01427.2006"},{"key":"e_1_2_6_15_2","first-page":"335","article-title":"Chronic spinal cord\u2010injured cats: surgical procedures and management","volume":"42","author":"Roy RR","year":"1992","journal-title":"Lab Anim Sci"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02446097"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00317.2003"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(71)90033-8"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.6.2509"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01113.2002"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90668.2008"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00862.2007"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91092.2008"},{"key":"e_1_2_6_24_2","first-page":"370","article-title":"Efficacy of functional electrical stimulation in ameliorating inactivity\u2010induced atrophy in a fast hindlimb muscle in rat","author":"Kim SJ","year":"2005","journal-title":"Proc IFESS Abstr"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20054"},{"key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1152\/jappl.1993.74.5.2509","article-title":"Activity\u2010induced regulation of myosin isoform distribution: comparison of two contractile activity programs","volume":"74","author":"Diffee GM","year":"1993","journal-title":"J Appl Physiol"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.6.4525"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1999.19430323.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.2310\/6650.2005.00309"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021266"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020424"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00324.2003"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00736.2007"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21293"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20040274"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20976"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6604com"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/387083a0"},{"key":"e_1_2_6_39_2","first-page":"R601","article-title":"Skeletal muscle myostatin mRNA expression is fiber\u2010type specific and increases during hindlimb unloading","volume":"277","author":"Carlson CJ","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(00)00044-6"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2560045.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.6.2237"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21720","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.21720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T09:06:38Z","timestamp":1696842398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.21720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,24]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1002\/mus.21720"],"URL":"https:\/\/doi.org\/10.1002\/mus.21720","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,24]]}}}