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The most common complication is some degree of skeletal muscle myopathy, ranging from painless serum creatine kinase elevations to rhabdomyolysis. Unfortunately, the likelihood and\/or severity of complications increases with the combination of statin treatment and physical activity. The specific pathways that mediate statin\u2010associated myopathy are unclear, and research directly addressing the exacerbation with exercise is limited. Potential mechanisms include the induction of skeletal muscle fiber apoptosis, alterations in ubiquitin\u2013proteasome pathway activity, mitochondrial dysfunction, and terpenoid depletion. In this review we provide an overview of research that specifically addresses the combination of statin\u2010associated myopathy and physical activity and highlight some deficiencies in the available literature, as well as future directions for this important subset of statin\u2010associated myopathy. 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