{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:04:17Z","timestamp":1789887857151,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T00:00:00Z","timestamp":1292544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Muscle pain is a common side effect of statin medications, but the cause is poorly understood. We characterized phosphocreatine (PCr) exercise recovery kinetics in 10 patients with hypercholesterolemia before and after a 4\u2010week regimen of statin therapy using 31\u2010phosphorus magnetic resonance spectroscopy (<jats:sup>31<\/jats:sup>P\u2010MRS). <jats:sup>31<\/jats:sup>P spectra were obtained before, during, and after exercise on a calf flexion pedal ergometer. Creatine kinase (CK) serum levels were drawn before and after statin therapy. The mean metabolic recovery time constant in subjects increased from 28.1 s (SE = 6.5 s) to 55.4 s (SE = 7.4 s) after statin therapy. The unweighted mean of the pre\/post\u2010recovery time difference was \u221227.3 s (SE = 12.4 s; <jats:italic>P<\/jats:italic> = 0.02). Pre\u2010 and post\u2010therapy CK levels were not significantly different (<jats:italic>P<\/jats:italic> = 0.50). Metabolic recovery time in the calf is prolonged in patients after statin use. This suggests that statins impair mitochondrial oxidative function, and <jats:sup>31<\/jats:sup>P MRS is a potential study model for statin\u2010associated myopathy. Muscle Nerve, 2011<\/jats:p>","DOI":"10.1002\/mus.21847","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T05:30:54Z","timestamp":1292823054000},"page":"76-81","source":"Crossref","is-referenced-by-count":50,"title":["Evaluation of skeletal muscle during calf exercise by 31\u2010phosphorus magnetic resonance spectroscopy in patients on statin medications"],"prefix":"10.1002","volume":"43","author":[{"given":"Jim S.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Buettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Smithline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long H.","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Greenman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000180661.65425.05"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.21.2585"},{"key":"e_1_2_6_4_2","first-page":"142","article-title":"Severe rhabdomyolysis associated with the cerivastin\u2013gemfibrozil combination therapy: report of a case","volume":"28","author":"Lau TK","year":"2001","journal-title":"Tex Heart Inst J"},{"key":"e_1_2_6_5_2","first-page":"258","article-title":"Statin myopathies: pathophysiologic and clinical perspectives","volume":"24","author":"Baker SK","year":"2001","journal-title":"Clin Invest Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011908004965"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/10.1161\/01.ATV.0000194548.11901.a4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1681"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200022060-00003"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01428-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02828.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20291"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200225090-00004"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.03.006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100124"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-128843"},{"key":"e_1_2_6_17_2","first-page":"3940","article-title":"The muscle\u2010specific ubiquitin ligase atrogin\u20101\/MAFbx mediates statin\u2010induced muscle toxicity","volume":"117","author":"Hanai J","year":"2007","journal-title":"J Clin Invest"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.081785"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-7-200210010-00009"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200105000-00017"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2007.04.010"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200412000-00008"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1109"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910010303"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.12.069"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170802"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072789.89096.10"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.06.006"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67696-9"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.01.020"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000162616.20085.B4"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1387"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.76.1.35"},{"key":"e_1_2_6_34_2","first-page":"77","article-title":"Bioenergetics of intact human muscle. 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