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Segmental conduction times were calculated in normal subjects; in patients with lumbosacral radiculopathy, distal symmetric diabetic neuropathy, amyotrophic lateral sclerosis, acute and chronic inflammatory demyelinating polyneuropathy; and in patients with anti\u2013myelin\u2010associated glycoprotein, myelomatous, and Charcot\u2013Marie\u2013Tooth type 1a polyneuropathies. <jats:italic>Results<\/jats:italic>: Distal cauda equina latency and CMAP duration and segmental conduction times in upper leg and cauda equina facilitated differentiation of demyelinating from axonal neuropathies, even in the presence of a range of reduced amplitude CMAPs. <jats:italic>Conclusions<\/jats:italic>: Within the demyelinating neuropathy spectrum, it was further possible to distinguish subtypes. 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