{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T22:39:47Z","timestamp":1772145587995,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:00:00Z","timestamp":1297123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:italic>Introduction<\/jats:italic>:<\/jats:title><jats:p>Lesions of peripheral nerves cause loss of motor and sensory function and also lead to hyperreflexia and hyperalgesia. Activity\u2010dependent therapies promote axonal regeneration and functional recovery and may improve sensory\u2013motor coordination and restoration of adequate circuitry at the spinal level.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Methods<\/jats:italic>:<\/jats:title><jats:p>We compared the effects of passive (bicycle) and active (treadmill) exercise on nerve regeneration and modulation of the spinal H reflex after transection and repair of the rat sciatic nerve. Animals were evaluated during 2 months using electrophysiological, functional, and histological methods.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Results<\/jats:italic>:<\/jats:title><jats:p>Moderate exercise for 1 hour\/day, either active treadmill walking or passive cycling, improved muscle reinnervation, increased the number of regenerated axons in the distal nerve, and reduced the increased excitability of spinal reflexes after nerve lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Discussion<\/jats:italic>:<\/jats:title><jats:p>Maintenance of denervated muscle activity and afferent input, by active or passive exercise, may increase trophic factor release to act on regenerating axons and to modulate central neuronal plasticity. Muscle Nerve, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.21912","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T08:06:33Z","timestamp":1297325193000},"page":"500-509","source":"Crossref","is-referenced-by-count":86,"title":["Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat"],"prefix":"10.1002","volume":"43","author":[{"given":"Esther","family":"Udina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Puigdemasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1163"},{"key":"e_1_2_6_3_2","volume-title":"Nerve and nerve injuries","author":"Sunderland S","year":"1978"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/089771502320914705"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2003.03027.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03052-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.06.005"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02602.2000"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00775.2003"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.01.020"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.05.034"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003677-200410000-00006"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01587-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.12.011"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(1998)18:5<334::AID-MICR7>3.0.CO;2-N"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(81)90073-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199907)22:7<846::AID-MUS6>3.0.CO;2-I"},{"key":"e_1_2_6_18_2","first-page":"151","article-title":"Autotomy prevention by amitriptyline after peripheral nerve section in different strains of mice","volume":"6","author":"Navarro X","year":"1994","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20010115)63:2<214::AID-JNR1014>3.0.CO;2-D"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/089771503765355568"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"e_1_2_6_22_2","first-page":"187","article-title":"Histological assessment of sciatic nerve regeneration following resections and graft or tube repair in the mouse","volume":"10","author":"G\u00f3mez N","year":"1996","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.008"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00942.2003"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01190468"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217322"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.02.013"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(97)90013-7"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/74.1.50"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/41.7.8515044"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/51A.1.B43"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0035-2"},{"key":"e_1_2_6_33_2","first-page":"125","article-title":"Electrostimulation\u2010induced changes in the enzyme activity pattern of dystrophic mouse muscles","volume":"28","author":"Reichmann H","year":"1983","journal-title":"Acta Histochem Suppl"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10114"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1987.tb08118.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91166-2"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-198908000-00005"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1139\/h96-018"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1942.02830420023006"},{"key":"e_1_2_6_40_2","first-page":"463","article-title":"Effect of increased motor activity on regeneration of the peripheral nerve in young rats","volume":"12","author":"Gutmann E","year":"1963","journal-title":"Physiol Bohemoslov"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401443101"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20521"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0711"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(73)90176-3"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.11.1247"},{"key":"e_1_2_6_46_2","first-page":"255","article-title":"Histochemical fiber type alterations secondary to exercise training of reinnervating adult rat muscle","volume":"61","author":"Herbison GJ","year":"1980","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(80)90176-4"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120709"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90236-W"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90074-X"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970615)48:6<524::AID-JNR5>3.0.CO;2-C"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(98)80008-9"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.12.016"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.07.006"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-1174-y"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199902)22:2<230::AID-MUS11>3.0.CO;2-R"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20369"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141113"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20436"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2006.01657.x"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903380206"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20678"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00482.2006"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10308"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013084"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198315010-00011"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968305280753"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00264.2003"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00152.2002"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7943"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199908)22:8<1000::AID-MUS2>3.0.CO;2-Q"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.21912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.21912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:30:21Z","timestamp":1696926621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.21912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,8]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/mus.21912"],"URL":"https:\/\/doi.org\/10.1002\/mus.21912","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,8]]}}}