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MRI was conducted prior to exercise, immediately afterward (\u223d20 minutes), and then 24 and 48 hours after exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A higher percentage of pixels with elevated T<jats:sub>2<\/jats:sub> in the lower hindlimb muscles was observed in the <jats:italic>mdx<\/jats:italic> mice compared with controls both pre\u2010exercise (<jats:italic>P<\/jats:italic> &lt; 0.001) and at each time\u2010point after downhill running (<jats:italic>P<\/jats:italic> &lt; 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Downhill running provides a stimulus for inducing acute changes in muscle T<jats:sub>2<\/jats:sub> in <jats:italic>mdx<\/jats:italic> mice. MRI is a non\u2010invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously. Muscle Nerve, 2010.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.21986","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T17:31:37Z","timestamp":1302629497000},"page":"878-886","source":"Crossref","is-referenced-by-count":71,"title":["Changes in muscle T2 and tissue damage after downhill running in <i>mdx<\/i> Mice"],"prefix":"10.1002","volume":"43","author":[{"given":"Sunita","family":"Mathur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravneet S.","family":"Vohra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean A.","family":"Germain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan 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