{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:50:57Z","timestamp":1777668657617,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T00:00:00Z","timestamp":1300060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction:<\/jats:title><jats:p>Myotonic dystrophy, or dystrophia myotonica (DM), is characterized by prominent muscle wasting and weakness as well as delayed muscle relaxation resulting from persistent electrical discharges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We hypothesized heterogeneity among muscles in degree of weakness and myotonia in an expanded [(CUG)<jats:sub>250<\/jats:sub>] repeats transgenic (<jats:italic>HSA<\/jats:italic><jats:sup><jats:italic>LR<\/jats:italic><\/jats:sup>) mouse DM model. Muscle contraction was compared among diaphragm, extensor digitorum longus (EDL), and soleus muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Myotonia was found only in EDL, as manifested by longer late\u2010relaxation time and elevated myotonic index. EDL, but not the other two muscles, had impaired force over a wide range of stimulation frequencies. During fatigue\u2010inducing stimulation, DM EDL muscle force per cross\u2010sectional area was significantly impaired during 25\u2010Hz stimulation, whereas there were no differences in fatigue response for DM diaphragm or soleus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>In an expanded repeats model of DM the EDL is more susceptible to myotonia and force impairment than muscles with lower proportions of fast\u2010twitch fibers. Muscle Nerve, 2011<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.21988","type":"journal-article","created":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T20:01:58Z","timestamp":1300132918000},"page":"818-827","source":"Crossref","is-referenced-by-count":11,"title":["Differential susceptibility of muscles to myotonia and force impairment in a mouse model of myotonic dystrophy"],"prefix":"10.1002","volume":"43","author":[{"given":"Michelle","family":"Moyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dara S.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea N.","family":"Ladd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Van 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