{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:27:57Z","timestamp":1791912477715,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:00:00Z","timestamp":1308009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Introduction: Myasthenia gravis (MG) patients with autoantibodies to muscle\u2010specific tyrosine kinase (MuSK) represent a distinct subset of those with this disease. Treatment and outcomes data in these patients are limited and conflicting. Methods: We reviewed 110 MuSK\u2010MG patients from two large clinics in Italy and the USA. Results: Thirty\u2010nine to 49% of patients with generalized, acetylcholine receptor antibody (AChR\u2010Ab)\u2013negative MG had MuSK\u2010MG. Eighty\u2010five percent were female, with disease onset typically in the fourth decade. Ocular and\/or bulbar symptoms were present at onset in 79% of those studied. Eighty\u2010five percent were MGFA class III or greater, and crisis occurred in 28%. Plasma exchange (PLEX) produced improvement in 93%, whereas only 61% improved after intravenous immunoglobulin. Long\u2010term outcomes were comparable to those of patients with AChR\u2010Ab\u2013positive MG. Conclusions: MuSK\u2010MG has a marked female predominance with frequent oculobulbar weakness and crises. Many patients deteriorate rapidly early in the disease, and PLEX is usually the preferred treatment. Long\u2010term outcomes are similar to those of patients with AChR\u2010Ab\n                    <jats:sup>+<\/jats:sup>\n                    MG. Muscle Nerve 44: 36\u201340, 2011\n                  <\/jats:p>","DOI":"10.1002\/mus.22006","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T05:58:37Z","timestamp":1308117517000},"page":"36-40","source":"Crossref","is-referenced-by-count":318,"title":["Anti\u2010musk antibody myasthenia gravis: Clinical findings and response to treatment in two large cohorts"],"prefix":"10.1002","volume":"44","author":[{"given":"Jeffrey T.","family":"Guptill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Evoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880171208"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg223"},{"key":"e_1_2_6_4_2","first-page":"A418","article-title":"Muscle specific tyrosine kinase (MuSK) positive, seronegative myasthenia gravis. Clinical characteristics and response to therapy","volume":"60","author":"Sanders DB","year":"2003","journal-title":"Neurology"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.052415"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000254620.45529.97"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21642"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21371"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.190298"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21545"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000180660.57801.3f"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21533"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.057"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","volume-title":"Approach to diseases of the neuromuscular junction.","author":"Sanders DB","DOI":"10.1002\/9781119973331.ch15"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000065882.63904.53"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000183145.91579.74"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833c0982"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.06.003"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21191"},{"key":"e_1_2_6_21_2","first-page":"A91","article-title":"Musk\u2010antibody positive myasthenia gravis and their clinical features in North India","volume":"74","author":"Suhail H","year":"2010","journal-title":"Neurology"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.22006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.22006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:07:26Z","timestamp":1696907246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.22006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,14]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1002\/mus.22006"],"URL":"https:\/\/doi.org\/10.1002\/mus.22006","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,14]]}}}