{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:45:42Z","timestamp":1760121942586,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T00:00:00Z","timestamp":1313625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001080","name":"Donaghue Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001080","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung and Blood Institute","doi-asserted-by":"crossref","award":["RO1HL081893","RC1AT005836-01"],"award-info":[{"award-number":["RO1HL081893","RC1AT005836-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Center for Medical Rehabilitation Research\/National Institute of Neurological Disorders"},{"name":"Stroke Integrated Molecular Core for Rehabilitation Medicine","award":["5R24 HD050846"],"award-info":[{"award-number":["5R24 HD050846"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Introduction: Hydroxymethylglutaryl\u2013coenzyme A (HMG\u2010CoA) reductase inhibitors, or statins, are widely used drugs for hyperlipidemia and are generally well\u2010tolerated, but the can produce skeletal muscle toxicity. The molecular mechanisms driving statin myopathy are unknown. We investigated the effects of statin treatment and eccentric (damaging) exercise on transcriptional patterns between statin myopathy (Sym; <jats:italic>N<\/jats:italic> = 9) and statin\u2010tolerant subjects (Asym; <jats:italic>N<\/jats:italic> = 6). Methods: Skeletal muscle biopsies were collected 6 h post\u2010exercise at baseline and after statin treatment. Subjects performed concentric (non\u2010damaging) exercise with one leg and concentric + eccentric exercise with the other leg using a cross\u2010over design between time\u2010points. Results: Sym as compared with Asym demonstrated decreased skeletal muscle gene expression for oxidative phosphorylation\u2013related and mitochondrial ribosomal protein genes before and after statin treatment with eccentric exercise. Conclusions: These results suggest that pre\u2010existing deficiencies in energy production may contribute to the development of symptoms during statin therapy, especially when muscle is exposed to eccentric exercise. Muscle Nerve 44: 393\u2013401, 2011<\/jats:p>","DOI":"10.1002\/mus.22081","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T15:48:21Z","timestamp":1299512901000},"page":"393-401","source":"Crossref","is-referenced-by-count":21,"title":["Transcriptional deficits in oxidative phosphorylation with statin myopathy"],"prefix":"10.1002","volume":"44","author":[{"given":"Monica J.","family":"Hubal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Biase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherie","family":"Bilbie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla M.","family":"Clarkson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric P.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02030-2"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1681"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-005-5686-z"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2003.02044.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00180.2006"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-007-0050-3"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00226.2006"},{"key":"e_1_2_7_9_2","first-page":"258","article-title":"Statin myopathies: pathophysiologic and clinical perspectives","volume":"24","author":"Baker SK","year":"2001","journal-title":"Clin Invest Med"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.02.013"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000190608.28704.71"},{"key":"e_1_2_7_12_2","first-page":"3940","article-title":"The muscle\u2010specific ubiquitin ligase atrogin\u20101\/MAFbx mediates statin\u2010induced muscle toxicity","volume":"117","author":"Hanai JI","year":"2007","journal-title":"J Clin Invest"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.164699"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.03.006"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.06.003"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000101287"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20567"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90218-3"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00865404"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0730383"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10472"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.624890"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90061-9"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.06.008"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.08.013"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01083-8"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.164699"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00352-4"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-7-200210010-00009"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2003.11.019"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116882"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5237-6"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000117016"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.203.65.1"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05474.x"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000042050.85041.FB"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/15376510802305047"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00847.2007"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0604-584"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.45.31853"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.08.001"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.22081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.22081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.22081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:57:09Z","timestamp":1696885029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.22081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,18]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1002\/mus.22081"],"URL":"https:\/\/doi.org\/10.1002\/mus.22081","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"type":"print","value":"0148-639X"},{"type":"electronic","value":"1097-4598"}],"subject":[],"published":{"date-parts":[[2011,8,18]]}}}