{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T07:06:21Z","timestamp":1756191981686,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University College London Hospitals\/University College London"},{"name":"Department of Health's National Institute for Health Research Biomedical Research Centers"},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["5U54 RR019498-05"],"award-info":[{"award-number":["5U54 RR019498-05"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council, MRC Centre","award":["G0601943"],"award-info":[{"award-number":["G0601943"]}]},{"name":"Clinical Investigation of Neurological Channelopathies","award":["NIH U45 RR198442-01"],"award-info":[{"award-number":["NIH U45 RR198442-01"]}]},{"name":"UK Department of Health National Commissioning Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: A proximal myopathy develops in some patients with muscle channelopathies, but the causative molecular mechanisms are unknown. <jats:italic>Methods<\/jats:italic>: We reviewed retrospectively all clinical and muscle biopsy findings of 3 patients with channelopathy and additional myositis. Direct DNA sequencing was performed. <jats:italic>Results<\/jats:italic>: Pathogenic mutations were identified in each case. Biopsies demonstrated inflammatory infiltrates. <jats:italic>Conclusions<\/jats:italic>: Clinicians should consider muscle biopsy in channelopathy patients with severe myalgia and\/or subacute weakness and accompanying elevated creatine kinase. Chance association of myositis and channelopathy is statistically unlikely. An alternative hypothesis suggests that inflammatory insults could contribute to myopathy in some patients. 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