{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:04:37Z","timestamp":1761217477689},"reference-count":90,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T00:00:00Z","timestamp":1321574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Introduction: Cobalamin (Cbl) deficiency affects the peripheral nervous system (PNS) morphologically and functionally. We investigated whether the octapeptide repeat (OR) region of prion protein (PrP<jats:sup>C<\/jats:sup>) (which is claimed to have myelinotrophic properties) is involved in the pathogenesis of rat Cbl\u2010deficient (Cbl\u2010D) polyneuropathy. Methods: We intracerebroventricularly administered antibodies (Abs) against the OR region (OR\u2010Abs) to Cbl\u2010D rats to prevent myelin damage and maximum nerve conduction velocity (MNCV) abnormalities, and PrP<jats:sup>C<\/jats:sup>s to normal rats to reproduce PNS Cbl\u2010D\u2013like lesions. We measured nerve PrP<jats:sup>C<\/jats:sup> levels and MNCV. Results: The OR\u2010Abs normalized myelin ultrastructure, MNCV values, and tumor necrosis factor (TNF)\u2010\u03b1 levels in the sciatic and tibial nerves of Cbl\u2010D rats. PrP<jats:sup>C<\/jats:sup> levels increased in Cbl\u2010D nerves. The nerves of the PrP<jats:sup>C<\/jats:sup>\u2010treated rats showed typical Cbl\u2010D lesions, significantly decreased MNCV values, and significantly increased TNF\u2010\u03b1 levels. Conclusions: OR\u2010Abs prevent the myelin damage caused by increased OR regions, and excess TNF\u2010\u03b1 is involved in the pathogenesis of Cbl\u2010D polyneuropathy. Muscle Nerve 2011<\/jats:p>","DOI":"10.1002\/mus.22225","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T19:50:55Z","timestamp":1310154655000},"page":"957-967","source":"Crossref","is-referenced-by-count":6,"title":["The octapeptide repeat PrP<sup>C<\/sup> region and cobalamin\u2010deficient polyneuropathy of the rat"],"prefix":"10.1002","volume":"44","author":[{"given":"Giuseppe","family":"Scalabrino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Veber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Rodriguez Menendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Novembrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Calligaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Tredici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,18]]},"reference":[{"issue":"69","key":"e_1_2_6_2_2","first-page":"1","article-title":"Neurological complications in patients with impaired vitamin B12 absorption following partial gastrectomy","volume":"59","author":"Roos D","year":"1978","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-002-0036-y"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2006.11.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.05.001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.04.004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130213"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20845"},{"key":"e_1_2_6_9_2","first-page":"297","article-title":"Subacute combined degeneration and induction of ornithine decarboxylase in spinal cords of totally gastrectomized rats","volume":"62","author":"Scalabrino G","year":"1990","journal-title":"Lab Invest"},{"key":"e_1_2_6_10_2","first-page":"165","article-title":"Subacute combined degeneration in totally gastrectomized rats: an ultrastructural study","volume":"30","author":"Tredici G","year":"1998","journal-title":"J Submicrosc Cytol Pathol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00005-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1096\/fj.02-0231fje","article-title":"Decreased GFAP\u2010mRNA expression in spinal cord of cobalamin\u2010deficient rats","volume":"16","author":"Magnaghi V","year":"2002","journal-title":"FASEB J"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.2.297"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.11.029"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.14.2083"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00095-4"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20025"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2002.5655"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125620"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00007.2007"},{"key":"e_1_2_6_21_2","first-page":"63","article-title":"Prion protein: orchestrating neurotrophic activities","volume":"12","author":"Martins VR","year":"2010","journal-title":"Curr Issues Mol Biol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf324"},{"key":"e_1_2_6_23_2","first-page":"297","article-title":"Prions prevent brain damage after experimental brain injury: a preliminary report","volume":"86","author":"Hoshino S","year":"2003","journal-title":"Acta Neurochir"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10864"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0605-5"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2007.02.011"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.06.019"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41040441.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200202)23:2<339::AID-ELPS339>3.0.CO;2-Y"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81859-0"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.4161\/pri.1.2.4346"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/356577a0"},{"key":"e_1_2_6_33_2","first-page":"689","article-title":"A mouse prion protein transgene rescues mice deficient for the prion protein gene from Purkinje cell degeneration and demyelination","volume":"79","author":"Nishida N","year":"1999","journal-title":"Lab Invest"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2007.04.004"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2483"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90177-5"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/362543a0"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0433"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073725"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.04.020"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091007"},{"key":"e_1_2_6_42_2","first-page":"51","article-title":"Prion neurotoxicity: insights from prion protein mutants","volume":"12","author":"Solomon IH","year":"2010","journal-title":"Curr Issues Mol Biol"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.5.2434-2439.2002"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00155-0"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90307-0"},{"key":"e_1_2_6_46_2","first-page":"114","article-title":"Subacute combined degeneration in the spinal cords of totally gastrectomized rats. Ornithine decarboxylase induction, cobalamin status, and astroglial reaction","volume":"72","author":"Scalabrino G","year":"1995","journal-title":"Lab Invest"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199802000-00004"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00360-5"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.03.011"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00046-5"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003872"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00061.x"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00261.x"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.6376"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.04.055"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.0636l.x"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02956170"},{"key":"e_1_2_6_58_2","series-title":"Ergebnisse der Anatomie und Entwicklungsgeschichte","first-page":"302","author":"Plenk H","year":"1927"},{"key":"e_1_2_6_59_2","first-page":"435","article-title":"Silver staining of the endoneuril fibers of the cerebrospinal nerves","volume":"6","author":"Laidlaw GF","year":"1930","journal-title":"Am J Pathol"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094273"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.4161\/pri.1.3.4870"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9387-0"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201544"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl226"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000267642.41594.9d"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007059827541"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02089-0"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601510"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(05)80225-2"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.9.1296"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.17.5.309"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.134528"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1342"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(84)90147-3"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290058014"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-11-2813"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.2.828-833.2000"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063093"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/35089090"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01457"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200822010-00005"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.83578-0"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.32.19173"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000579200"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0328-05.2005"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.04.002"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007243200"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biolcel.2003.11.007"},{"key":"e_1_2_6_89_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720508783954749"},{"key":"e_1_2_6_90_2","doi-asserted-by":"publisher","DOI":"10.2307\/3001478"},{"key":"e_1_2_6_91_2","first-page":"20","volume-title":"Statistical methods","author":"Snedecor GW","year":"1971"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.22225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.22225","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.22225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:25:19Z","timestamp":1697433919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.22225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,18]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1002\/mus.22225"],"URL":"https:\/\/doi.org\/10.1002\/mus.22225","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,18]]}}}