{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:15:40Z","timestamp":1791029740216,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:00:00Z","timestamp":1331856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: The purpose of this study was to test the hypothesis that malignant hyperthermia model mice (RyR1Y522S\/wt) are more vulnerable to exercise\u2010induced muscle injury and fatigability and adapt less to run training. <jats:italic>Methods<\/jats:italic>: After 6 weeks of voluntary wheel running, we measured anterior crural muscle fatigability, muscle injury, and cytochrome oxidase (COX) and citrate synthase (CS). <jats:italic>Results<\/jats:italic>: Although RyR1Y522S\/wt mice ran without undergoing MH episodes, they ran 42% less distance than wild\u2010type (WT) mice. Muscles from WT mice exhibited increased fatigue resistance and COX content after training. Muscles from RyR1Y522S\/wt mice demonstrated no significant change in fatigability or COX and CS after training. However, muscles from RyR1Y522S\/wt mice displayed less intrinsic fatigability and greater COX\/CS content and muscle damage than WT mice. <jats:italic>Conclusions<\/jats:italic>: RyR1Y522S\/wt mice can run without having rhabdomyolysis, and their inability to adapt to training appears to stem from intrinsic enhancement of mitochondrial enzymes and fatigue resistance. 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