{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T22:15:10Z","timestamp":1786227310102,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: There is much research on quality of life in myasthenia gravis (MG), and its relationship to disease severity is well\u2010established. However, evidence regarding sleep disturbance in MG is inconclusive. <jats:italic>Methods<\/jats:italic>: To evaluate sleep and quality of life among clinically stable MG patients, 54 subjects were investigated by means of the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and 15\u2010Item\u2010Quality\u2010Of\u2010Life Instrument for MG (MG\u2010QOL15). <jats:italic>Results<\/jats:italic>: A pathological PSQI score, which was observed in 59% of patients, was increased in subjects with active disease compared with patients in clinical remission [odds ratio = 4.3; confidence interval 95% (1.0\u201317.6); <jats:italic>P<\/jats:italic> = 0.04]. We found a relationship between PSQI and MG\u2010QOL15 scores in patients with clinically active disease (r = 0.62; <jats:italic>P<\/jats:italic> &lt; 0.001). <jats:italic>Conclusions<\/jats:italic>: Our study highlights the high prevalence of sleep disturbance among MG patients. Disease severity may be considered to be a MG\u2010specific risk factor for patient\u2010reported sleep disturbance. The MG\u2010QOL15 and PSQI should be used to estimate the impact of the disease on sleep and quality of life. Muscle Nerve 46: 174\u2013180, 2012<\/jats:p>","DOI":"10.1002\/mus.23296","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T13:51:07Z","timestamp":1325857867000},"page":"174-180","source":"Crossref","is-referenced-by-count":64,"title":["Myasthenia gravis: Sleep quality, quality of life, and disease severity"],"prefix":"10.1002","volume":"46","author":[{"given":"Elena Hern\u00e1ndez","family":"Mart\u00ednez\u2010Lapiscina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elena","family":"Erro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ayuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Jeric\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0167-y"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-010-0285-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5279-z"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21016"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21053"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21609"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21883"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050181"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310116"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000223515.15691.26"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01666.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077937"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.02.018"},{"key":"e_1_2_6_18_2","first-page":"S145","article-title":"Respiratory disorders during sleep and myasthenia [Troubles respiratoires pendant le sommeil et myasthenia]","volume":"157","author":"Gajdos P","year":"2001","journal-title":"Rev Neuro (Paris)"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000050461.05432.C5"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176067.32186.a3"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:06:42Z","timestamp":1696907202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,16]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/mus.23296"],"URL":"https:\/\/doi.org\/10.1002\/mus.23296","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,16]]}}}