{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:57:19Z","timestamp":1791089839813,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T00:00:00Z","timestamp":1345420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction:<\/jats:title><jats:p>The effect of recovery time on neuromuscular function after a fatiguing task was compared in both the upper and lower limbs between patients with Charcot\u2013Marie\u2013Tooth type 1A (CMT1A) and healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Torque of elbow flexors and knee extensors and surface electromyography (sEMG) data of biceps brachii and vastus lateralis were recorded from 8 CMT1A patients and 8 matched, healthy individuals during maximal voluntary contraction (MVC) before (pre\u2010fatigue MVC), 10 s after (10\u2010s post\u2010fatigue MVC), and 10 min after (10\u2010min post\u2010fatigue MVC) a fatiguing task at 80% MVC until exhaustion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Only in the lower limb, torque and root mean square of sEMG (RMS) during pre\u2010fatigue MVC were lower (<jats:italic>P<\/jats:italic> &lt; 0.05) in patients (91.93 \u00b1 45.95 Nm, 0.11 \u00b1 0.07 mV) than in controls (161.06 \u00b1 75.5 Nm, 0.24 \u00b1 0.16 mV). In the 10\u2010min post\u2010fatigue MVC, muscle\u2010fiber conduction velocity (MFCV) and RMS, expressed as a percentage of pre\u2010fatigue MVC, were lower (<jats:italic>P<\/jats:italic> &lt; 0.05) in patients (MFCV 90.3 \u00b1 6.91%, RMS 84.50 \u00b1 9.89%) than in controls (MFCV 100.87 \u00b1 5.1%, RMS 92.71 \u00b1 11.84%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>CMT1A patients are not only weaker than healthy individuals in the knee extensors, but they also have impaired neuromuscular recovery after fatigue. 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