{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:29:51Z","timestamp":1761128991035},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction:<\/jats:title><jats:p>Immune\u2010mediated myopathies are a heterogeneous group of chronic autoimmune disorders. Autoantibodies associated with this disease complex are classified into myositis\u2010associated and myositis\u2010specific. Anti\u2010tRNA synthetase antibodies are the most well known of the myositis\u2010specific antibodies. Previous reports have revealed an association of tRNA synthetase autoantibodies with systemic connective tissue disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Our case report involved a 49\u2010year\u2010old man who developed difficulty walking and climbing stairs 5 months prior to his initial visit. No rash or skin changes were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Laboratory testing was positive for anti\u2010PL12 autoantibody with a negative evaluation for connective tissue disorder (CTD). The patient was found to have necrotizing myopathy associated with anti\u2010PL12 antibodies in the absence of inflammatory changes on biopsy, significant derangement of muscle enzymes, or findings characteristic of a typical CTD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>A high index of suspicion must be maintained for immune\u2010mediated necrotizing myopathy despite the absence of an identifiable CTD and milder symptoms. Muscle Nerve 46: 282\u2013286, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.23383","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T06:48:31Z","timestamp":1331880511000},"page":"282-286","source":"Crossref","is-referenced-by-count":15,"title":["Isolated necrotizing myopathy associated with ANTI\u2010PL12 antibody"],"prefix":"10.1002","volume":"46","author":[{"given":"Prachi","family":"Mehndiratta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil V.","family":"Manjila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary M.","family":"Kammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000212374"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.169375"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1666-1"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2233"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.1.7"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200310000-00002"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1062267"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.04.005"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27572"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197202172860701"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.2"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199111000-00002"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1811-4"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181af7c7c"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep078"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-011-0119-8"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.03.001"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23383","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:07:26Z","timestamp":1696907246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,16]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/mus.23383"],"URL":"https:\/\/doi.org\/10.1002\/mus.23383","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,16]]}}}