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The aim of this study was to verify whether urinary 8\u2010hydroxydeoxyguanosine (8\u2010OHdG), an oxidative stress marker, is a biomarker for SBMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We measured the levels of urinary 8\u2010OHdG in 33 genetically confirmed SBMA patients and 32 age\u2010matched controls over a 24\u2010month period at 6\u2010month intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Urinary 8\u2010OHdG levels in SBMA patients were significantly elevated compared with those of controls and correlated well with motor function scores. During the follow\u2010up period, urinary 8\u2010OHdG levels increased and correlated with motor function at each time\u2010point. In addition, urinary 8\u2010OHdG levels at baseline were correlated with changes in the 6\u2010minute walk test during 24 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Urinary 8\u2010OHdG is a biomarker for SBMA, reflecting the severity and possibly predicting the deterioration of motor function. 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