{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T09:39:15Z","timestamp":1697535555374},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> HMG\u2010CoA reductase inhibitors are the most frequently prescribed drugs for treatment of lipid imbalance, but they have side effects, such as myopathy. Our aim was to assess the effect of simvastatin on the inflammatory process induced by skeletal muscle injury. <jats:italic>Methods:<\/jats:italic> Rats were divided into experimental groups [control group, simvastatin (20 mg\/kg) group, group treated with simvastatin (20 mg\/kg) and subjected to injury, and group subjected to injury only]. Histological analysis and analyses of creatine kinase activity and C\u2010reactive protein were performed. <jats:italic>Results:<\/jats:italic> Animals treated with simvastatin exhibited significantly greater morphological and structural skeletal muscle damage in comparison to the control group and injured animals without treatment. <jats:italic>Conclusions:<\/jats:italic> Although simvastatin has a small anti\u2010inflammatory effect in the early stage after a muscle strain injury, the overall picture is negative, as simvastatin increases the extent of damage to muscle morphology. Further studies are needed. Muscle Nerve, 2012<\/jats:p>","DOI":"10.1002\/mus.23444","type":"journal-article","created":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T12:00:44Z","timestamp":1336392044000},"page":"899-907","source":"Crossref","is-referenced-by-count":0,"title":["Effect of simvastatin on passive strain\u2010induced skeletal muscle injury in rats"],"prefix":"10.1002","volume":"46","author":[{"given":"Shaiane Silva","family":"Tomazoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto Cesar Pinto","family":"Leal\u2010Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney Capp","family":"Pallotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"De Godoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Paolo","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00dacio","family":"Frigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Sardinha","family":"Leonardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"De Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo \u00c1lvaro Brand\u00e3o","family":"Lopes\u2010Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.2.B54"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2002157"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00226.2006"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/009127002401102731"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059344"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380010602"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200225090-00004"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0299"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10228"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.12.048"},{"key":"e_1_2_6_13_2","first-page":"2933","article-title":"Exercise\u2010induced injury to skeletal muscle","volume":"45","author":"McCully KK","year":"1986","journal-title":"Fed Proc"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001433-200110000-00008"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.12.004"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10436"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2001.00825.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"R345","DOI":"10.1152\/ajpregu.00454.2004","article-title":"Inflammatory processes in muscle injury and repair","volume":"2","author":"Tidball JG","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20080150"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/036354658701500102"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.081785"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1681"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.179"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20810"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2010.3294"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.1.64"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.3632"}],"container-title":["Muscle &amp; 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