{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:56:06Z","timestamp":1783032966932,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Intrinsic mouse complement regulators influence the severity of passively induced experimental acquired myasthenia gravis (EAMG). To assess the potential influence of CD59b in the absence of CD59a background, we used the\n                      <jats:italic>mCD59ab<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mouse model to re\u2010evaluate mCD59 in protecting the neuromuscular junction (NMJ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      EAMG was induced with monoclonal antibody to the acetylcholine receptor (AChR) in\n                      <jats:italic>Daf1<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ,\n                      <jats:italic>CD59ab<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ,\n                      <jats:italic>\n                        Daf1\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                        CD59ab\n                      <\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      , and wild\u2010type C57Bl\/6 mice. Animals were monitored throughout the experiment. Diaphragms were analyzed for NMJ injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        Daf1\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                        CD59ab\n                      <\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice required euthanasia 24 hours after disease induction because of severe weakness. Histological assessment demonstrated reduced AChR density, simplification of synaptic folds, and disrupted mitochondria. CD59ab\u2010deficient mice demonstrated mild weakness and reduction in weight after 24 hours. In contrast,\n                      <jats:italic>Daf1<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      had more severe weakness at 60 hours. The NMJ of EAMG\u2010induced\n                      <jats:italic>Daf1<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      and\n                      <jats:italic>CD59ab<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice demonstrated similar AChR density.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NMJs of CD59 and DAF mice are protected from complement\u2010mediated injury of passive EAMG. Muscle Nerve, 2013<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.23448","type":"journal-article","created":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T08:04:15Z","timestamp":1336377855000},"page":"33-40","source":"Crossref","is-referenced-by-count":22,"title":["Cell surface complement regulators moderate experimental myasthenia gravis pathology"],"prefix":"10.1002","volume":"47","author":[{"given":"Linda L.","family":"Kusner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Kaminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903555943"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903518081"},{"key":"e_1_2_6_4_2","first-page":"267","article-title":"Immune complexes (IgG and C3) at the motor end\u2010plate in myasthenia gravis: ultrastructural and light microscopic localization and electrophysiologic correlations","volume":"52","author":"Engel AG","year":"1977","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10962.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.06.005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.06.003"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216086"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03205.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.05.006"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.4.1.43"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(99)00005-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.5.1221"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.3.637"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.4049\/jimmunol.144.5.1823","article-title":"Purification of 1F5 antigen that prevents complement attack on homologous cell membranes","volume":"144","author":"Harada R","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114172"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.1.151"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2732"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.3684"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00022-0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21363"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364296"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01287.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/285238a0"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(96)00144-0"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.43.7.577"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.764"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2011.01.002"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2620"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8027.2000.00018.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21536"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.10.014"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.003"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262888"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.12.8562"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.142.8.2654"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.06.144"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02519-09"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.10.014"}],"container-title":["Muscle &amp; 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