{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:07:04Z","timestamp":1770437224470,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T00:00:00Z","timestamp":1345420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Introduction: In this study we describe a patient with a prolonged myasthenic crisis refractory to conventional immunomodulatory therapy who was treated with GM\u2010CSF (granulocyte macrophage colony\u2010stimulating factor, sargramostim). Methods: T\u2010regulatory cell (Treg) suppressive function and Foxp3 expression were evaluated before and after treatment with GM\u2010CSF. Results: Treatment with GM\u2010CSF was associated with clinical improvement, expansion in the circulating numbers of Foxp3<jats:sup>+<\/jats:sup> cells, increase in Foxp3 expression levels in Tregs, early improvement in Treg suppressive capacity for AChR\u2010\u03b1\u2013induced T\u2010cell proliferation, and subsequent enhancement in Treg suppression of polyclonal T\u2010cell proliferation. Conclusion: Although definitive conclusions cannot be drawn from a single case, the correlation with similar findings in GM\u2010CSF\u2013treated animals with experimental autoimmune myasthenia gravis suggests further exploration of the effects of GM\u2010CSF in myasthenia gravis should be studied in a clinical trial setting. Muscle Nerve 46: 449\u2013453, 2012<\/jats:p>","DOI":"10.1002\/mus.23488","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T17:17:21Z","timestamp":1339435041000},"page":"449-453","source":"Crossref","is-referenced-by-count":61,"title":["Granulocyte macrophage colony\u2010stimulating factor treatment of a patient in myasthenic crisis: Effects on regulatory T cells"],"prefix":"10.1002","volume":"46","author":[{"given":"Julie","family":"Rowin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthusamy","family":"Thiruppathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebinehita","family":"Arhebamen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bellur S.","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew N.","family":"Meriggioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,20]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxn147"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.3638"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5296"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.03.509"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.057"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113807"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02690.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.006"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-006-0041-4"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2579"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23488","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T15:22:55Z","timestamp":1696864975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,20]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1002\/mus.23488"],"URL":"https:\/\/doi.org\/10.1002\/mus.23488","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,20]]}}}