{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:00:09Z","timestamp":1761102009456},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinician Investigator Program of the University of British Columbia"},{"name":"Bisby fellowship from the Canadian Institutes of Health Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Patients with mitochondrial myopathies may develop cardiac complications such as cardiomyopathy and\/or cardiac conduction defects. To identify these potentially life\u2010threatening and treatable conditions, it is common practice to screen patients intermittently with electrocardiography and echocardiography. The optimal time interval for such screening investigations is unknown. We developed this study to review our screening results in adult\u2010onset patients with progressive external ophthalmoplegia (PEO). <jats:italic>Methods:<\/jats:italic> This study was a retrospective review of PEO patients with 5 years or more of cardiac screening investigations who did not have any cardiac symptoms. <jats:italic>Results:<\/jats:italic> Fifteen patients were included, and cardiomyopathy was identified on screening echocardiogram in 1 patient. Four patients had other abnormalities identified, which were unrelated to their mitochondrial myopathy. <jats:italic>Conclusions:<\/jats:italic> Only 1 patient in 15 developed cardiac complications related to mitochondrial disease during 5 years of follow\u2010up. We suggest that a screening interval of 3\u20135 years is probably appropriate for adult\u2010onset PEO patients who do not have cardiac symptoms. Muscle Nerve 60: 608\u2013611, 2012<\/jats:p>","DOI":"10.1002\/mus.23538","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T23:14:08Z","timestamp":1343690048000},"page":"593-596","source":"Crossref","is-referenced-by-count":9,"title":["Cardiac screening investigations in adult\u2010onset progressive external ophthalmoplegia patients"],"prefix":"10.1002","volume":"46","author":[{"given":"Gerald","family":"Pfeffer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Mezei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710001115X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d0ccf4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059477"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.05.012"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.4.955"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(94)00080-S"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273970500216432"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-008-0289-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm067"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.166066"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/513872"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23538","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:52:23Z","timestamp":1696909943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,13]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/mus.23538"],"URL":"https:\/\/doi.org\/10.1002\/mus.23538","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,13]]}}}