{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:54:35Z","timestamp":1751478875409,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["AR-41802"],"award-info":[{"award-number":["AR-41802"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Nitric oxide (NO) signaling regulates many biological processes in skeletal muscle, wherein aberrant signaling contributes to myopathic conditions (e.g., Duchenne muscular dystrophy). NO has been shown to play a role in muscle regeneration after injury. However, less is known about its role during injury. In this study we aimed to determine whether NO synthase (NOS) inhibition exacerbates functional deficits immediately after the performance of eccentric contractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Wild\u2010type mouse extensor digitorum longus (EDL) muscles underwent <jats:italic>in vitro<\/jats:italic> functional testing in the presence or absence of a non\u2010specific NOS inhibitor (L\u2010NAME, 10 mM) before and after performance of 10 eccentric contractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After eccentric contractions, P<jats:sub>o<\/jats:sub> was reduced by \u223d25% for muscle in regular physiological solution but by \u223d50% with the addition of L\u2010NAME (<jats:italic>P<\/jats:italic> = 0.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010specific blockade of NOS exacerbates functional deficits immediately after eccentric contractions, suggesting that NO signaling protects skeletal muscle from excessive injury in healthy muscle. Muscle Nerve, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.23655","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T09:32:30Z","timestamp":1346146350000},"page":"271-273","source":"Crossref","is-referenced-by-count":5,"title":["Immediate force loss after eccentric contractions is increased with l\u2010name administration, a nitric oxide synthase inhibitor"],"prefix":"10.1002","volume":"47","author":[{"given":"Benjamin T.","family":"Corona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Ingalls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.209"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.1.C260"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.2.E390"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2433468100"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00667.2011"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00513.2005"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2010.11.003"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(97)00136-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20425"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.3.C806"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00018.2004"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020943"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.1.58"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019783"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90320.2008"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00365.2009"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00462.2000"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00671.2001"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91266-S"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0700896"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.14.6.525"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00096.2011"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.64.4.427"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019645"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.4.1445"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23655","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:08:50Z","timestamp":1696928930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/mus.23655"],"URL":"https:\/\/doi.org\/10.1002\/mus.23655","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"type":"print","value":"0148-639X"},{"type":"electronic","value":"1097-4598"}],"subject":[],"published":{"date-parts":[[2013,1,24]]}}}