{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:03Z","timestamp":1790985603581,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Although it is known that continuous noninvasive ventilation (CNIV) can prolong life in amyotrophic lateral sclerosis\/motor neuron disease (ALS\/MND), in this study we explore similar claims for diaphragm pacing (DP). Methods: NIV and DP users' vital capacities (VCs) over time and duration of NIV and CNIV dependence were analyzed for 354 non\u2010DP and 8 DP ALS\/MND patients. Results: Patients had a higher rate of monthly VC decline before NIV use (5.1 \u00b1 7.6%) than during NIV use (2.5 \u00b1 3.6%) (<jats:italic>P<\/jats:italic> &lt; 0.01, 95% CI 0.84\u20134.5); the decline for 4 DP users was 3.7\u201320%. Fifty\u2010five ALS\/MND patients used part\u2010time NIV for 19.9 \u00b1 27.6 months until tracheostomy\/death, whereas 113 others used it for 10.9 \u00b1 10.5 months until CNIV dependence for another 12.8 \u00b1 16.2 months. After placement, 7 DP users were CNIV dependent in 8.0 \u00b1 7.0 months, whereas 6 underwent tracheostomy\/died in 18.2 \u00b1 13.7 months. Conclusions: CNIV prolonged the survival of 113 of the 354 non\u2010DP and 6 DP ALS\/MND patients by 12.8 and 10.2 months, respectively. DP provided no benefit on VC or mechanical ventilation\u2013free survival. Muscle Nerve, 2012<\/jats:p>","DOI":"10.1002\/mus.23663","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T08:13:49Z","timestamp":1346314429000},"page":"841-850","source":"Crossref","is-referenced-by-count":22,"title":["Diaphragm pacing and noninvasive respiratory management of amyotrophic lateral sclerosis\/motor neuron disease"],"prefix":"10.1002","volume":"46","author":[{"given":"Kedar R.","family":"Mahajan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Robert","family":"Bach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lou","family":"Saporito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.2.521"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00045-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-0223-3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200203-175CR"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.1996.tb00187.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.4.1230"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.1.61"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000076182.13137.38"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000227785.73714.64"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.2.508"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.5.1502"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197203092861004"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2011.597862"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3181d8a479"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1983.58.1.0092"},{"key":"e_1_2_5_17_2","first-page":"946","article-title":"Influence of phrenic nerve stimulation in diaphragm blood flow","author":"Sairenji H","year":"1983","journal-title":"Prog Artif Org"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.12.1427"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.1.92"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.6.1552"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23663","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:22:39Z","timestamp":1697476959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,5]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/mus.23663"],"URL":"https:\/\/doi.org\/10.1002\/mus.23663","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,5]]}}}