{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:14:21Z","timestamp":1772813661003,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: We aimed to determine the effect of different botulinum toxin\u2010A (BTX\u2010A) dilutions on the treatment efficacy and side effects for amyotrophic lateral sclerosis (ALS) related sialorrhea. <jats:italic>Methods<\/jats:italic>: Ten patients were enrolled in the study. BTX\u2010A dilution for Group A was 100 U in 1 ml of saline, whereas the dilution for Group B was 100 U in 2 ml of saline. Both groups received 20 U of BTX\u2010A in each parotid gland, and assessments were made by means of the Drooling Impact Scale, items 1 and 3 of the ALS functional rating scale, and visual analog scales for drooling and swallowing function. <jats:italic>Results<\/jats:italic>: Although both groups exhibited a similar improvement in drooling, Group B had a mild but significant deterioration in bulbar function that was not evident in Group A. <jats:italic>Conclusions<\/jats:italic>: These results suggest that BTX\u2010A has a safer profile when reconstituted with 1 ml instead of 2 ml of saline. Muscle Nerve, 2013<\/jats:p>","DOI":"10.1002\/mus.23692","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T19:17:28Z","timestamp":1349723848000},"page":"276-278","source":"Crossref","is-referenced-by-count":23,"title":["Volume matters: The influence of different botulinum toxin\u2010A dilutions for sialorrhea in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"47","author":[{"given":"Anagnostou","family":"Evangelos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rentzos","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexakis","family":"Theodoros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zouvelou","family":"Vasiliki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zambelis","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evdokimidis","family":"Ioannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C019"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(97)90103-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000280411.57836.aa"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.05.005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/17482960903264998"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00565-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e318164a931"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PHM.0000141128.62598.81"},{"key":"e_1_2_6_10_2","unstructured":"Package insert on Botox Irvine California USA Allergan Inc; October2010."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20545"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.1.121"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.cnd.0000188865.88167.62"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0738-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21213"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23692","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:08:52Z","timestamp":1696928932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,28]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/mus.23692"],"URL":"https:\/\/doi.org\/10.1002\/mus.23692","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,28]]}}}