{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T01:11:33Z","timestamp":1769908293605,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>: Crotamine is a basic, low\u2010molecular\u2010weight peptide that, at low concentrations, improves neurotransmission in isolated neuromuscular preparations by modulating sodium channels. In this study, we compared the effects of crotamine and neostigmine on neuromuscular transmission in myasthenic rats. <jats:italic>Methods<\/jats:italic>: We used a conventional electromyographic technique in <jats:italic>in\u2010situ<\/jats:italic> neuromuscular preparations and a 4\u2010week treadmill program. <jats:italic>Results<\/jats:italic>: During the <jats:italic>in\u2010situ<\/jats:italic> electromyographic recording, neostigmine (17 \u03bcg\/kg) caused short\u2010term facilitation, whereas crotamine induced progressive and sustained twitch\u2010tension enhancement during 140 min of recording (50 \u00b1 5%, <jats:italic>P<\/jats:italic> &lt; 0.05). On the treadmill evaluation, rats showed significant improvement in exercise tolerance, characterized by a decrease in the number of fatigue episodes after 2 weeks of a single\u2010dose treatment with crotamine. <jats:italic>Conclusions<\/jats:italic>: These results indicate that crotamine is more efficient than neostigmine for enhancing muscular performance in myasthenic rats, possibly by improving the safety factor of neuromuscular transmission. Muscle Nerve, 2013<\/jats:p>","DOI":"10.1002\/mus.23714","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T10:16:47Z","timestamp":1352283407000},"page":"591-593","source":"Crossref","is-referenced-by-count":12,"title":["Beneficial effect of crotamine in the treatment of myasthenic rats"],"prefix":"10.1002","volume":"47","author":[{"given":"Saraguaci","family":"Hernandez\u2010Oliveira e Silva","sequence":"first","affiliation":[{"name":"Departamento de Farmacologia Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paolo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Rostelato\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paolo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomaz Augusto Alves","family":"Rocha\u2010e\u2010Silva","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paolo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila","family":"Randazzo\u2010Moura","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paolo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ch\u00c1riston Andr\u00c9","family":"Dal\u2010Belo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Pampa Campus S\u00e3o Gabriel S\u00e3o Gabriel Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eladio Flores","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias Centro de Pesquisa e Desenvolvimento Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline R.","family":"Borja\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Escola de Artes Ci\u00eancias e Humanidades Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00c9a","family":"Rodrigues\u2010Simioni","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paolo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"502","volume-title":"Clinic anesthesia","author":"Dierdorf SF","year":"2006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32832f15fa"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.05.022"},{"key":"e_1_2_7_5_1","first-page":"291","article-title":"Neuromuscular action of the Crotalus terrificus terrificus poisons","volume":"1","author":"Barrio A","year":"1951","journal-title":"Acta Physiol Latinoam"},{"key":"e_1_2_7_6_1","first-page":"253","article-title":"The electrophoretic analysis of snake venoms","volume":"13","author":"Gon\u00e7alves JM","year":"1947","journal-title":"Arch Biochem"},{"key":"e_1_2_7_7_1","first-page":"365","article-title":"Estudos sobre venenos de serpentes brasileiras. 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