{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:30:51Z","timestamp":1765827051286},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T00:00:00Z","timestamp":1367539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A single local corticosteroid injection is an effective treatment for carpal tunnel syndrome. No study has specifically examined the effectiveness of a second injection on relapse after primary injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified a cohort of patients who had received an initial corticosteroid injection into 1 wrist and then, at a later date, a second injection into the same wrist. We compared the change in the Boston Symptom Severity Scale (SSS) and Functional Status Scale (FSS) between first and second injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 229 patients who received 2 injections the mean improvement on the SSS was 1.2 (SD = 0.8) for the first injection and 1.3 (SD = 0.9) for the second, which was not statistically significant. Improvement in FSS for the first injection was 0.4 (SD = 0.8) and 0.7 (SD = 0.8) for the second, which was statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Second corticosteroid injections appear to be at least as effective as the first. <jats:italic>Muscle Nerve<\/jats:italic>, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.23725","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T05:01:19Z","timestamp":1353301279000},"page":"122-126","source":"Crossref","is-referenced-by-count":9,"title":["Effectiveness of second corticosteroid injections for carpal tunnel syndrome"],"prefix":"10.1002","volume":"48","author":[{"given":"Nigel L.","family":"Ashworth","sequence":"first","affiliation":[{"name":"Division Physical Medicine and Rehabilitation University of Alberta 10230 111 Avenue Edmonton T5G 0B7 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy D.P.","family":"Bland","sequence":"additional","affiliation":[{"name":"EEG Department East Kent Hospitals University NHS Trust Canterbury Kent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD001554","article-title":"Local corticosteroid injection for carpal tunnel syndrome","volume":"2","author":"Marshall S","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0062-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.08.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10512"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22183"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062070-00020"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(90)90061-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(05)80202-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(94)90054-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh571"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000101055.76543.C7"},{"key":"e_1_2_6_13_1","first-page":"287","article-title":"Effect of local corticosteroid injection on median nerve conduction in carpal tunnel syndrome","volume":"6","author":"Goodman HV","year":"1962","journal-title":"Ann Phys Med"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193409102380"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20408"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200008)23:8<1280::AID-MUS20>3.0.CO;2-Y"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(00)80009-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.12.1674"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22158"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199311000-00002"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-78"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7214.884"},{"key":"e_1_2_6_23_1","first-page":"906","volume-title":"Applied regression analysis and other multivariable methods","author":"Kleinbaum DG","year":"2007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199804000-00005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679809002363"}],"container-title":["Muscle &amp; 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