{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:33:37Z","timestamp":1760783617984},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Antimitochondrial antibodies are autoantibodies detected in 90% of primary biliary cirrhosis (<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>) patients. Some <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> cases are complicated by myositis, which is difficult to confirm due to minimal histological evidence of inflammation in limb muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our aim was to determine the extent of inflammatory changes in a truncal muscle biopsy specimen from a <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 48\u2010year\u2010old woman with a 5\u2010year history of atrial fibrillation and chronic heart failure was evaluated for elevated serum creatine kinase level. Antimitochondrial <jats:styled-content style=\"fixed-case\">M2<\/jats:styled-content> antibodies were detected, and <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> was diagnosed. A biceps brachii biopsy specimen showed mild, non\u2010specific myogenic changes; a second biopsy was performed on the rectus abdominis muscle, which showed typical inflammatory changes. Myositis with antimitochondrial <jats:styled-content style=\"fixed-case\">M2<\/jats:styled-content> antibodies was confirmed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In myositis patients with antimitochondrial <jats:styled-content style=\"fixed-case\">M2<\/jats:styled-content> antibodies, muscles of the extremities are involved to a lesser extent. Radiological and histological examination focusing on truncal muscles, including a biopsy, is important. Muscle Nerve 47: 766\u2013768, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.23730","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T10:57:28Z","timestamp":1353495448000},"page":"766-768","source":"Crossref","is-referenced-by-count":20,"title":["Myositis with antimitochondrial antibodies diagnosed by rectus abdominis muscle biopsy"],"prefix":"10.1002","volume":"47","author":[{"given":"Takeshi","family":"Uenaka","sequence":"first","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine and Kobe University Hospital 7\u20105\u20102 Kusunoki\u2010cho Chuo\u2010Ku, Kobe Hyogo 650\u20100017 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisatomo","family":"Kowa","sequence":"additional","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine and Kobe University Hospital 7\u20105\u20102 Kusunoki\u2010cho Chuo\u2010Ku, Kobe Hyogo 650\u20100017 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine and Kobe University Hospital 7\u20105\u20102 Kusunoki\u2010cho Chuo\u2010Ku, Kobe Hyogo 650\u20100017 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kakuya","family":"Nagata","sequence":"additional","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine and Kobe University Hospital 7\u20105\u20102 Kusunoki\u2010cho Chuo\u2010Ku, Kobe Hyogo 650\u20100017 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine and Kobe University Hospital 7\u20105\u20102 Kusunoki\u2010cho Chuo\u2010Ku, Kobe Hyogo 650\u20100017 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine and Kobe University Hospital 7\u20105\u20102 Kusunoki\u2010cho Chuo\u2010Ku, Kobe Hyogo 650\u20100017 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsushi","family":"Toda","sequence":"additional","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine and Kobe University Hospital 7\u20105\u20102 Kusunoki\u2010cho Chuo\u2010Ku, Kobe Hyogo 650\u20100017 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"455","article-title":"A case of primary biliary cirrhosis with HLA\u2010DR 8 complicated by polymyositis","volume":"44","author":"Sato T","year":"2003","journal-title":"Liver"},{"key":"e_1_2_6_3_1","first-page":"287","article-title":"A male autopsy case of primary biliary cirrhosis associated with polymyositis and congestive cardiomyopathy","volume":"85","author":"Saitoh S","year":"1988","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0397-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0041-87811999000500007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361020"},{"key":"e_1_2_6_7_1","first-page":"694","article-title":"Polymyositis with marked paravertebral muscle atrophy in patients with primary biliary cirrhosis","volume":"40","author":"Matsui K","year":"2000","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws106"}],"container-title":["Muscle &amp; 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