{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:28:41Z","timestamp":1791210521472,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,29]],"date-time":"2013-06-29T00:00:00Z","timestamp":1372464000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,6,29]],"date-time":"2013-06-29T00:00:00Z","timestamp":1372464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle Nerve"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1002\/mus.23748","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T14:50:37Z","timestamp":1355410237000},"page":"272-278","source":"Crossref","is-referenced-by-count":30,"title":["Diaphragm muscle atrophy in the mouse after long-term mechanical ventilation"],"prefix":"10.1002","volume":"48","author":[{"given":"Huibin","family":"Tang","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery; Department of Cardiothoracic Surgery; Stanford School of Medicine, VA Palo Alto Health Care System; 300 Pasteur Drive Stanford California 94305-5407 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery; Department of Cardiothoracic Surgery; Stanford School of Medicine, VA Palo Alto Health Care System; 300 Pasteur Drive Stanford California 94305-5407 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Khuong","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery; Department of Cardiothoracic Surgery; Stanford School of Medicine, VA Palo Alto Health Care System; 300 Pasteur Drive Stanford California 94305-5407 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Wright","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery; Department of Cardiothoracic Surgery; Stanford School of Medicine, VA Palo Alto Health Care System; 300 Pasteur Drive Stanford California 94305-5407 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Shrager","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery; Department of Cardiothoracic Surgery; Stanford School of Medicine, VA Palo Alto Health Care System; 300 Pasteur Drive Stanford California 94305-5407 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,29]]},"reference":[{"key":"10.1002\/mus.23748-BIB0001|mus23748-cit-0001","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1183\/09031936.02.00063102","article-title":"Effects of mechanical ventilation on diaphragm function and biology","volume":"20","author":"Gayan-Ramirez","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1002\/mus.23748-BIB0002|mus23748-cit-0002","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1164\/rccm.200210-1246OC","article-title":"Is weaning failure caused by low-frequency fatigue of the diaphragm?","volume":"167","author":"Laghi","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0003|mus23748-cit-0003","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1378\/chest.88.5.736","article-title":"Diaphragmatic strength during weaning from mechanical ventilation","volume":"88","author":"Swartz","year":"1985","journal-title":"Chest"},{"key":"10.1002\/mus.23748-BIB0004|mus23748-cit-0004","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/cc660","article-title":"Weaning from mechanical ventilation","volume":"4","author":"Al\u00eda","year":"2000","journal-title":"Crit Care"},{"key":"10.1002\/mus.23748-BIB0005|mus23748-cit-0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1056\/NEJM199502093320601","article-title":"A comparison of four methods of weaning patients from mechanical ventilation","volume":"332","author":"Esteban","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1002\/mus.23748-BIB0006|mus23748-cit-0006","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1378\/chest.116.2.447","article-title":"Four-year experience with a unit for long-term ventilation (respiratory special care unit) at the Cleveland Clinic Foundation","volume":"116","author":"Dasgupta","year":"1999","journal-title":"Chest"},{"key":"10.1002\/mus.23748-BIB0007|mus23748-cit-0007","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1378\/chest.122.1.192","article-title":"Use of inspiratory muscle strength training to facilitate ventilator weaning: a series of 10 consecutive patients","volume":"122","author":"Martin","year":"2002","journal-title":"Chest"},{"key":"10.1002\/mus.23748-BIB0008|mus23748-cit-0008","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1378\/chest.111.6.1654","article-title":"Post-ICU mechanical ventilation: treatment of 1,123 patients at a regional weaning center","volume":"111","author":"Scheinhorn","year":"1997","journal-title":"Chest"},{"key":"10.1002\/mus.23748-BIB0009|mus23748-cit-0009","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc3917","article-title":"Bench-to-bedside review: weaning failure-should we rest the respiratory muscles with controlled mechanical ventilation?","volume":"10","author":"Vassilakopoulos","year":"2006","journal-title":"Crit Care"},{"key":"10.1002\/mus.23748-BIB0010|mus23748-cit-0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/ptj\/83.2.171","article-title":"Use of inspiratory strength training to wean six patients who were ventilator-dependent","volume":"83","author":"Sprague","year":"2003","journal-title":"Phys Ther"},{"issue":"suppl","key":"10.1002\/mus.23748-BIB0011|mus23748-cit-0011","doi-asserted-by":"crossref","first-page":"482S","DOI":"10.1378\/chest.120.6_suppl.482S","article-title":"Post-ICU weaning from mechanical ventilation: the role of long-term facilities","volume":"120","author":"Scheinhorn","year":"2001","journal-title":"Chest"},{"key":"10.1002\/mus.23748-BIB0012|mus23748-cit-0012","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0749-0704(02)00016-7","article-title":"Liberation from prolonged mechanical ventilation","volume":"18","author":"Scheinhorn","year":"2002","journal-title":"Crit Care Clin"},{"key":"10.1002\/mus.23748-BIB0013|mus23748-cit-0013","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1164\/ajrccm.161.4.9812160","article-title":"Physiologic determinants of ventilator dependence in long-term mechanically ventilated patients","volume":"161","author":"Purro","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0014|mus23748-cit-0014","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/thx.2004.026500","article-title":"Outcomes, cost and long term survival of patients referred to a regional weaning centre","volume":"60","author":"Pilcher","year":"2005","journal-title":"Thorax"},{"key":"10.1002\/mus.23748-BIB0015|mus23748-cit-0015","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1378\/chest.116.2.456","article-title":"Predicting 3-day and 7-day outcomes of weaning from mechanical ventilation","volume":"116","author":"Afessa","year":"1999","journal-title":"Chest"},{"key":"10.1002\/mus.23748-BIB0016|mus23748-cit-0016","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1078-5337(05)70080-0","article-title":"Approach to patients with long-term weaning failure","volume":"6","author":"Scheinhorn","year":"2000","journal-title":"Respir Care Clin N Am"},{"key":"10.1002\/mus.23748-BIB0017|mus23748-cit-0017","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1097\/00003246-200212000-00008","article-title":"Survival and quality of life: short-term versus long-term ventilator patients","volume":"30","author":"Douglas","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0018|mus23748-cit-0018","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/apmr.2002.29614","article-title":"Weaning success among ventilator-dependent patients in a rehabilitation facility","volume":"83","author":"Modawal","year":"2002","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1002\/mus.23748-BIB0019|mus23748-cit-0019","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1097\/01.CCM.0000181731.53912.D9","article-title":"Clinical and economic consequences of ventilator-associated pneumonia: a systematic review","volume":"33","author":"Safdar","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0020|mus23748-cit-0020","first-page":"1","article-title":"Ventilator-associated pneumonia among elderly Medicare beneficiaries in long-term care hospitals","volume":"31","author":"Buczko","year":"2010","journal-title":"Health Care Financ Rev"},{"key":"10.1002\/mus.23748-BIB0021|mus23748-cit-0021","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1086\/651669","article-title":"Economic burden of ventilator-associated pneumonia based on total resource utilization","volume":"31","author":"Restrepo","year":"2010","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1002\/mus.23748-BIB0022|mus23748-cit-0022","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jcrc.2007.11.012","article-title":"The impact of ventilator-associated pneumonia on the Canadian health care system","volume":"23","author":"Muscedere","year":"2008","journal-title":"J Crit Care"},{"key":"10.1002\/mus.23748-BIB0023|mus23748-cit-0023","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1164\/rccm.200202-088OC","article-title":"Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity","volume":"166","author":"Shanely","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0024|mus23748-cit-0024","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00134-002-1547-4","article-title":"Effects of prolonged mechanical ventilation on respiratory muscle ultrastructure and mitochondrial respiration in rabbits","volume":"29","author":"Bernard","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1002\/mus.23748-BIB0025|mus23748-cit-0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00134-002-1548-3","article-title":"Effects of controlled mechanical ventilation on respiratory muscle contractile properties in rabbits","volume":"29","author":"Capdevila","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1002\/mus.23748-BIB0026|mus23748-cit-0026","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1097\/ALN.0b013e3181d7b036","article-title":"Adaptive support ventilation prevents ventilator-induced diaphragmatic dysfunction in piglet: an in vivo and in vitro study","volume":"112","author":"Jung","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1002\/mus.23748-BIB0027|mus23748-cit-0027","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1056\/NEJMoa070447","article-title":"Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans","volume":"358","author":"Levine","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1002\/mus.23748-BIB0028|mus23748-cit-0028","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1164\/rccm.201004-0670OC","article-title":"Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans","volume":"183","author":"Jaber","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"suppl","key":"10.1002\/mus.23748-BIB0029|mus23748-cit-0029","doi-asserted-by":"crossref","first-page":"S347","DOI":"10.1097\/CCM.0b013e3181b6e760","article-title":"Prolonged mechanical ventilation alters diaphragmatic structure and function","volume":"37","author":"Powers","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0030|mus23748-cit-0030","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1152\/japplphysiol.00993.2004","article-title":"Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm","volume":"98","author":"DeRuisseau","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.23748-BIB0031|mus23748-cit-0031","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1097\/CCM.0b013e318246bb5d","article-title":"Cross-talk between the calpain and caspase-3 proteolytic systems in the diaphragm during prolonged mechanical ventilation","volume":"40","author":"Nelson","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0032|mus23748-cit-0032","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1164\/rccm.200910-1487OC","article-title":"Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse","volume":"183","author":"Levine","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0033|mus23748-cit-0033","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1096\/fj.11-183798","article-title":"Intrinsic apoptosis in mechanically ventilated human diaphragm: linkage to a novel Fos\/FoxO1\/Stat3-Bim axis","volume":"25","author":"Tang","year":"2011","journal-title":"FASEB J"},{"key":"10.1002\/mus.23748-BIB0034|mus23748-cit-0034","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1096\/fj.11-197467","article-title":"Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems","volume":"26","author":"Tang","year":"2012","journal-title":"FASEB J"},{"key":"10.1002\/mus.23748-BIB0035|mus23748-cit-0035","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1164\/rccm.201002-0234OC","article-title":"Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy","volume":"182","author":"Hussain","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0036|mus23748-cit-0036","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.freeradbiomed.2009.01.002","article-title":"Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production","volume":"46","author":"Kavazis","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1002\/mus.23748-BIB0037|mus23748-cit-0037","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/ALN.0b013e318261e7f8","article-title":"Rapid onset of specific diaphragm weakness in a healthy murine model of ventilator-induced diaphragmatic dysfunction","volume":"117","author":"Mrozek","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1002\/mus.23748-BIB0038|mus23748-cit-0038","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/ALN.0b013e3182608cc0","article-title":"Toll-like receptor 4 signaling in ventilator-induced diaphragm atrophy","volume":"117","author":"Schellekens","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1002\/mus.23748-BIB0039|mus23748-cit-0039","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/CCM.0b013e3182190b62","article-title":"Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness","volume":"39","author":"Powers","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1002\/mus.23748-BIB0040|mus23748-cit-0040","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1378\/chest.121.1.210","article-title":"Sarcomeres are added in series to emphysematous rat diaphragm after lung volume reduction surgery","volume":"121","author":"Shrager","year":"2002","journal-title":"Chest"},{"key":"10.1002\/mus.23748-BIB0041|mus23748-cit-0041","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.resp.2004.06.012","article-title":"Persistence of diaphragmatic contraction influences the pulmonary inflammatory response to mechanical ventilation","volume":"142","author":"Br\u00e9geon","year":"2004","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1002\/mus.23748-BIB0042|mus23748-cit-0042","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1569-9048(02)00069-1","article-title":"Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription","volume":"132","author":"Br\u00e9geon","year":"2002","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1002\/mus.23748-BIB0043|mus23748-cit-0043","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1213\/00000539-200102000-00029","article-title":"Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta 1 mRNA upregulation in rat lungs","volume":"92","author":"Imanaka","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1002\/mus.23748-BIB0044|mus23748-cit-0044","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1096\/fj.06-7537com","article-title":"TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine","volume":"21","author":"Dogra","year":"2007","journal-title":"FASEB J"},{"key":"10.1002\/mus.23748-BIB0045|mus23748-cit-0045","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/japplphysiol.01026.2004","article-title":"IL-6-induced skeletal muscle atrophy","volume":"98","author":"Haddad","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.23748-BIB0046|mus23748-cit-0046","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1365-2443.2004.00792.x","article-title":"MFB-1, an F-box-type ubiquitin ligase, regulates TGF-beta signalling","volume":"9","author":"Aoyama","year":"2004","journal-title":"Genes Cells"}],"container-title":["Muscle & Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23748","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/mus.23748\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T17:40:50Z","timestamp":1593452450000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/mus.23748"}},"subtitle":["Mouse Diaphragm Atrophy"],"short-title":[],"issued":{"date-parts":[[2013,6,29]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"URL":"https:\/\/doi.org\/10.1002\/mus.23748","archive":["Portico"],"relation":{},"ISSN":["0148-639X"],"issn-type":[{"value":"0148-639X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,29]]}}}