{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T22:14:18Z","timestamp":1786227258916,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The clinical significance of striational antibodies (StrAbs) detected in the course of paraneoplastic antibody testing is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared all 203 striational antibody (StrAb)\u2010seropositive patients identified (2004\u20132005) during evaluation for paraneoplastic antibodies with age\u2010 and sex\u2010matched seronegative controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thymoma and myasthenia gravis (MG) were significantly more common among cases (<jats:italic>P<\/jats:italic>&lt;0.0001). Cancers more rarely detected after StrAb detection were adenocarcinoma in 5 patients and sarcoma in 3 patients. All patients who had a cancer identified after StrAb testing had a titer of \u22651:7680 or a coexisting muscle AChR\u2010binding antibody. Autoimmune disorders more commonly observed among cases (with any StrAb value) included: hypothyroidism; rheumatoid arthritis; and pernicious anemia (all <jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>StrAbs may serve as a diagnostic clue for an autoimmune diagnosis. There is a low likelihood of oncological significance in patients with StrAb titers &lt;1:7680 without coexisting paraneoplastic Abs. <jats:italic>Muscle Nerve<\/jats:italic>, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.23774","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T04:07:56Z","timestamp":1359605276000},"page":"585-587","source":"Crossref","is-referenced-by-count":39,"title":["Striational antibodies in a paraneoplastic context"],"prefix":"10.1002","volume":"47","author":[{"given":"Andrew","family":"McKeon","sequence":"first","affiliation":[{"name":"Department of Medicine and Pathology Mayo Clinic Hilton 3\u201078, 200 First Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda A.","family":"Lennon","sequence":"additional","affiliation":[{"name":"Department of Medicine and Pathology Mayo Clinic Hilton 3\u201078, 200 First Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"},{"name":"Department of Laboratory and Immunology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"LaChance","sequence":"additional","affiliation":[{"name":"Department of Medicine and Pathology Mayo Clinic Hilton 3\u201078, 200 First Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Medicine and Pathology Mayo Clinic Hilton 3\u201078, 200 First Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"Pittock","sequence":"additional","affiliation":[{"name":"Department of Medicine and Pathology Mayo Clinic Hilton 3\u201078, 200 First Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb51290.x"},{"key":"e_1_2_6_3_1","first-page":"331","article-title":"Paraneoplastic IgG striational autoantibodies produced by clonal thymic B cells and in serum of patients with myasthenia gravis and thymoma react with titin","volume":"66","author":"Williams CL","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.7.843"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb45504.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb18999.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0735"},{"key":"e_1_2_6_8_1","first-page":"S21","article-title":"Autoimmunity in the Lambert\u2013Eaton myasthenic syndrome","volume":"5","author":"Lennon V","year":"1982","journal-title":"Muscle Nerve"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20269"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.03.020"},{"key":"e_1_2_6_11_1","first-page":"1005","volume-title":"Manual of clinical laboratory immunology","author":"Griesmann G","year":"2002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21324"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20854"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65645-6"},{"issue":"3","key":"e_1_2_6_15_1","first-page":"118","article-title":"Penicillamine treatment of rheumatoid arthritis: relationship of proteinuria and autoantibodies to immune status","volume":"70","author":"Zilko PJ","year":"1977","journal-title":"Proc R Soc Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22239"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2008.03.006"},{"key":"e_1_2_6_18_1","first-page":"509","article-title":"Myoid cells in the human thymus and thymoma revealed by three different immunohistochemical markers for striated muscle","volume":"39","author":"Sato T","year":"1989","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11617"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02889011"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401611"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.021"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899226"}],"container-title":["Muscle &amp; 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