{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:07:29Z","timestamp":1791151649332,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cachexia increases morbidity and mortality of cancer patients. The progressive loss of muscle mass negatively affects physical function and quality of life. We previously showed reduced muscle insulin\u2010like growth factor\u20101 (IGF\u20101) expression and enhanced myostatin signaling in tumor\u2010bearing animals. This study was aimed at investigating whether similar perturbations occur in gastric cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Early perturbations of myostatin and IGF\u20101 signaling (including the expression of muscle\u2010specific ubiquitin ligases) were investigated in 16 gastric cancer patients and in 6 controls by analyzing muscle mRNA expression with semiquantitative reverse transcriptase polymerase chain reaction (PCR) and real\u2010time PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In gastric cancer patients, muscle mRNA levels for IGF\u20101, myostatin, and atrogin\u20101 were reduced irrespective of weight loss (\u22645% or &gt;5%), whereas MuRF1 expression was unchanged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      IGF\u20101 and myostatin mRNA levels are downregulated in gastric cancer patients who have minimal or no weight loss. These early alterations are particularly relevant in order to devise preventive and therapeutic strategies for cancer cachexia.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>48<\/jats:bold>\n                      : 387\u2013392, 2013\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.23798","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T22:52:43Z","timestamp":1359586363000},"page":"387-392","source":"Crossref","is-referenced-by-count":36,"title":["Early changes of muscle insulin\u2010like growth factor\u20101 and myostatin gene expression in gastric cancer patients"],"prefix":"10.1002","volume":"48","author":[{"given":"Andrea","family":"Bonetto","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine and Oncology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Penna","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Oncology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaira","family":"Aversa","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mercantini","sequence":"additional","affiliation":[{"name":"Department of Surgery, S. Andrea Hospital, Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco M.","family":"Baccino","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Oncology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Costelli","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Oncology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Ziparo","sequence":"additional","affiliation":[{"name":"Department of Surgery, S. Andrea Hospital, Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Lucia","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo Rossi","family":"Fanelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Muscaritoli","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2010.02.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.12.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.22.12699"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2010.04.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01386.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00104.2006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.134.4.1685"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151270098"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.23.12457"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040933"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.KR-110"},{"key":"e_1_2_6_14_1","first-page":"487","article-title":"Targeting myostatin for therapies against muscle\u2010wasting disorders","volume":"11","author":"Tsuchida K","year":"2008","journal-title":"Curr Opin Drug Discov Devel"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00107.2003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8077-3"},{"key":"e_1_2_6_17_1","first-page":"8","article-title":"Myostatin expression in age and denervation\u2010induced skeletal muscle atrophy","volume":"3","author":"Baumann AP","year":"2003","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4652(200009)184:3<356::AID-JCP10>3.0.CO;2-R"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800909789057015"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01970.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.123"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7701091"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1720-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22288"},{"key":"e_1_2_6_26_1","first-page":"8","article-title":"Myostatin expression in age and denervation\u2010induced skeletal muscle atrophy","volume":"3","author":"Baumann AP","year":"2003","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22796"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000055225.96357.71"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21893"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21293"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.10.017"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.10.047"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0406"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0869"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328338b9a6"}],"container-title":["Muscle &amp; 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