{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:53:07Z","timestamp":1777438387087,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Testosterone (T) induces motor dysfunction in transgenic (Tg) mice that overexpress wild\u2010type androgen receptor (AR) in skeletal muscles. Because many genes implicated in motor neuron disease are expressed in skeletal muscle, mutant proteins may act in muscle to cause dysfunction in motor neuron disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined contractile properties of the extensor digitorum longus (EDL) and soleus (SOL) muscles <jats:italic>in vitro<\/jats:italic> after 5 and 3 days of T treatment in motor\u2010impaired Tg female mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both muscles showed deficits in tetanic force after 5 days of T treatment, without losses in muscle mass, protein content, or fiber number. After 3 days of T treatment, only SOL showed a deficit in tetanic force comparable to that of 5 days of treatment. In both treatments, EDL showed slowed twitch kinetics, whereas SOL showed deficits in the twitch\/tetanus ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest calcium\u2010handling mechanisms in muscle fibers are defective in motor\u2010impaired mice. Muscle Nerve 47: 823\u2013834, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.23813","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T12:48:52Z","timestamp":1360327732000},"page":"823-834","source":"Crossref","is-referenced-by-count":21,"title":["Androgen receptors in muscle fibers induce rapid loss of force but not mass: Implications for spinal bulbar muscular atrophy"],"prefix":"10.1002","volume":"47","author":[{"given":"Kentaro","family":"Oki","sequence":"first","affiliation":[{"name":"Neuroscience Program, Michigan State University 108 Giltner Hall, 293 Farm Lane East Lansing Michigan 48824\u20101101 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Department of Physiology Michigan State University East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Marc","family":"Breedlove","sequence":"additional","affiliation":[{"name":"Neuroscience Program, Michigan State University 108 Giltner Hall, 293 Farm Lane East Lansing Michigan 48824\u20101101 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia L.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Neuroscience Program, Michigan State University 108 Giltner Hall, 293 Farm Lane East Lansing Michigan 48824\u20101101 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2315-06.2006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005390"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90869-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.5.1107"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705501104"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1885"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1876"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq106"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005344403603"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21540"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1547"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28773."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00834-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.101899"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0808-04.2004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.12.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313682"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00082-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.79.1.147"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7521"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2005.02.005"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.149286"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.3.R917"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.3.C878"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00500.2004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01267.2006"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2007.01592.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2008.08.004"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2006.12.002"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23061"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20088"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0084"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0018"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0071"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.1215"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711074105"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1916"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.05.014"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/352077a0"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.5.770"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21310"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.2.96"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.034"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(99)00132-7"}],"container-title":["Muscle &amp; 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