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Specific chemokine receptor antagonists have the potential to be efficacious against pathogenic leukocyte trafficking in GBS. Methods: A 36\u2010year literature review was performed to summarize available data on chemokine expression in GBS and its representative animal model, experimental autoimmune neuritis (EAN). Results: Although there were a few observational human and animal studies demonstrating chemokine ligand\/receptor expression in GBS and EAN, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> functional studies using gene knockouts, neutralizing antibodies, or small molecular antagonists were limited. CCL2\u2013CCR2, CCL5\u2013CCR5, and CXCL10\u2013CXCR3 have been most strongly implicated in EAN and GBS pathogenesis, providing targets for molecular blockade. Conclusions: Preclinical human <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> EAN studies are needed to evaluate the potential efficacy of chemokine signaling inhibition in GBS. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>48<\/jats:bold>: 320\u2013330, 2013<\/jats:p>","DOI":"10.1002\/mus.23829","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T21:47:59Z","timestamp":1362088079000},"page":"320-330","source":"Crossref","is-referenced-by-count":41,"title":["The role of chemokines in guillain\u2013barr\u00e9 syndrome"],"prefix":"10.1002","volume":"48","author":[{"given":"Sharon","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Statistics Rice University Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eroboghene E.","family":"Ubogu","sequence":"additional","affiliation":[{"name":"Neuromuscular Immunopathology Research Laboratory, Department of Neurology 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