{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:07:46Z","timestamp":1790755666818,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Complement activation at the neuromuscular junction is a primary cause of acetylcholine receptor loss and failure of neuromuscular transmission in myasthenia gravis (MG). Eculizumab, a humanized monoclonal antibody, blocks the formation of terminal complement complex by specifically preventing the enzymatic cleavage of complement 5 (C5). <jats:italic>Methods<\/jats:italic>: This study was a randomized, double\u2010blind, placebo\u2010controlled, crossover trial involving 14 patients with severe, refractory generalized MG (gMG). <jats:italic>Results<\/jats:italic>: Six of 7 patients treated with eculizumab for 16 weeks (86%) achieved the primary endpoint of a 3\u2010point reduction in the quantitative myasthenia gravis (QMG) score. Examining both treatment periods, the overall change in mean QMG total score was significantly different between eculizumab and placebo (<jats:italic>P<\/jats:italic>\u2009=\u20090.0144). After assessing data obtained from all visits, the overall change in mean QMG total score from baseline was found to be significantly different between eculizumab and placebo (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Eculizumab was well tolerated. <jats:italic>Conclusion<\/jats:italic>: The data suggest that eculizumab may have a role in treating severe, refractory MG. Muscle Nerve, 2013<\/jats:p>","DOI":"10.1002\/mus.23839","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T05:55:57Z","timestamp":1363758957000},"page":"76-84","source":"Crossref","is-referenced-by-count":204,"title":["A randomized, double\u2010blind, placebo\u2010controlled phase II study of eculizumab in patients with refractory generalized myasthenia gravis"],"prefix":"10.1002","volume":"48","author":[{"suffix":"Jr.","given":"James F.","family":"Howard","sequence":"first","affiliation":[{"name":"Department of Neurology University of North Carolina 2200 Physicians Office Building, CB 7025, 170 Manning Drive, Chapel Hill North Carolina 27599\u20107025 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Barohn","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kansas Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary 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