{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:47:30Z","timestamp":1789944450897,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30972859"],"award-info":[{"award-number":["30972859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Jiaotong University School of Medicine for PhD Graduates","award":["BXJ 201041"],"award-info":[{"award-number":["BXJ 201041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: We investigated a novel application of phrenic nerve stimulation (PNS) in diaphragm dysfunction induced by mechanical ventilation (MV). <jats:italic>Methods<\/jats:italic>: Twenty\u2010one Sprague\u2010Dawley rats were assigned randomly to 3 groups: spontaneous breathing, 18\u2010h controlled MV, and 18\u2010h controlled MV with PNS. Upon completion of the experimental protocol, diaphragm contractility, gene expression of insulin\u2010like growth factor\u20101 (IGF\u20101) and ubiquitin ligases, and serum IGF\u20101 levels were analyzed. <jats:italic>Results<\/jats:italic>: Compared with the spontaneously breathing rats, impaired diaphragm contractile function, including force\u2010related properties and force\u2010frequency responses, were pronounced with MV. Furthermore, MV suppressed IGF\u20101 and induced muscle ring finger 1 mRNA expression in the diaphragm. In contrast, PNS counteracted MV\u2010induced gene expression changes in the diaphragm and restored diaphragm function. <jats:italic>Conclusions<\/jats:italic>: PNS exerted a protective effect against MV\u2010induced diaphragm dysfunction by counteracting altered expression of IGF\u20101 and ubiquitin ligase in the diaphragm. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>48<\/jats:bold>: 958\u2013962, 2013<\/jats:p>","DOI":"10.1002\/mus.23850","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T09:57:35Z","timestamp":1363773455000},"page":"958-962","source":"Crossref","is-referenced-by-count":46,"title":["Phrenic nerve stimulation protects against mechanical ventilation\u2010induced diaphragm dysfunction in rats"],"prefix":"10.1002","volume":"48","author":[{"given":"Meirong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology First People's Hospital, School of Medicine, Shanghai Jiaotong University 100 Hai Ning Road Shanghai 200080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology First People's Hospital, School of Medicine, Shanghai Jiaotong University 100 Hai Ning Road Shanghai 200080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology First People's Hospital, School of Medicine, Shanghai Jiaotong University 100 Hai Ning Road Shanghai 200080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology First People's Hospital, School of Medicine, Shanghai Jiaotong University 100 Hai Ning Road Shanghai 200080 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